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1,3-Difluoro-2-propanol

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From Wikipedia, the free encyclopedia

1,3-Difluoro-2-propanol

Names

Preferred IUPAC name

1,3-Difluoropropan-2-ol

Identifiers

CAS Number

453-13-4^N

3D model (JSmol)

ChemSpider

61300^Y

ECHA InfoCard

100.006.561

PubChem CID

67985

UNII

R8ZM2LQG7K^Y

CompTox Dashboard(EPA)

DTXSID1060009

InChI

InChI=1S/C3H6F2O/c4-1-3(6)2-5/h3,6H,1-2H2^Y
Key: PVDLUGWWIOGCNH-UHFFFAOYSA-N^Y
InChI=1/C3H6F2O/c4-1-3(6)2-5/h3,6H,1-2H2
Key: PVDLUGWWIOGCNH-UHFFFAOYAJ

SMILES

OC(CF)CF
FCC(O)CF

Properties

Chemical formula

C₃H₆F₂O

Molar mass

96.077 g·mol⁻¹

Density

1.24 g/cm³ (at 25 °C)^[1]

Boiling point

54 to 55 °C (129 to 131 °F; 327 to 328 K)

Hazards

Flash point

42 °C (108 °F; 315 K)

Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).

N verify (what is ^YN ?)

Infobox references

Chemical compound

1,3-Difluoro-2-propanol is ametabolic poison which disrupts thecitric acid cycle and is used as arodenticide, similar tosodium fluoroacetate. It is the main ingredient (along with 1-chloro-3-fluoro-2-propanol) in the rodenticide productGliftor which was widely used in the former USSR^[2]^[3]^[4] and still approved in China.^[5]

References

[edit]

^Sigma Aldrich
^Buklan AI, Kravets AF (1986). "[Gliftor poisoning]".Sudebno-Meditsinskaia Ekspertiza (in Russian).29 (1):55–6.PMID 3961873.
^Feldwick MG, Noakes PS, Prause U, Mead RJ, Kostyniak PJ (1998). "The biochemical toxicology of 1,3-difluoro-2-propanol, the major ingredient of the pesticide gliftor: the potential of 4-methylpyrazole as an antidote".Journal of Biochemical and Molecular Toxicology.12 (1):41–52.doi:10.1002/(SICI)1099-0461(1998)12:1<41::AID-JBT6>3.0.CO;2-P.PMID 9414486.S2CID 29455648.
^Menon KI, Feldwick MG, Noakes PS, Mead RJ (2001). "The mode of toxic action of the pesticide gliftor: the metabolism of 1,3-difluoroacetone to (−)-erythro-fluorocitrate".Journal of Biochemical and Molecular Toxicology.15 (1):47–54.doi:10.1002/1099-0461(2001)15:1<47::AID-JBT6>3.0.CO;2-E.PMID 11170315.S2CID 9064673.
^Wood, Alan."Gliftor".Compendium of Pesticide Common Names. Retrieved14 June 2021.