| [tyrosine 3-monooxygenase] kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.11.6 | ||||||||
| CAS no. | 103537-12-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDBPDBePDBsum | ||||||||
| Gene Ontology | AmiGO /QuickGO | ||||||||
| |||||||||
Inenzymology, a[tyrosine 3-monooxygenase] kinase (EC2.7.11.6) is anenzyme thatcatalyzes thechemical reaction
Thus, the twosubstrates of this enzyme areATP andtyrosine 3-monooxygenase, whereas its twoproducts areADP andphospho-(tyrosine-3-monooxygenase).
This enzyme belongs to the family oftransferases, specifically those transferring a phosphate group to the sidechainoxygen atom ofserine orthreonine residues inproteins (protein-serine/threonine kinases). Thesystematic name of this enzyme class isATP:[tyrosine-3-monoxygenase] phosphotransferase. Other names in common use includepheochromocytoma tyrosine hydroxylase-associated kinase,STK4, andtyrosine 3-monooxygenase kinase (phosphorylating). This enzyme participates inMAPK signaling pathway andnon-small cell lung cancer.
