Inenzymology, a(S)-2-hydroxy-fatty-acid dehydrogenase (EC1.1.1.99) is anenzyme thatcatalyzes thechemical reaction

(S)-2-hydroxystearate + NAD⁺${\displaystyle \rightleftharpoons }$ 2-oxostearate + NADH + H⁺

Thus, the twosubstrates of this enzyme are(S)-2-hydroxystearate andNAD⁺, whereas its 3products are2-oxostearate,NADH, andH⁺.

This enzyme belongs to the family ofoxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. Thesystematic name of this enzyme class is(S)-2-hydroxystearate:NAD⁺ oxidoreductase. Other names in common use includedehydrogenase, L-2-hydroxy fatty acid,L-2-hydroxy fatty acid dehydrogenase, and2-hydroxy fatty acid oxidase.

• Huang WY, Tang J (1970)."Carboxyl-terminal sequence of human gastricsin and pepsin".J. Biol. Chem.245 (9):2189–93.doi:10.1016/S0021-9258(18)63137-0.PMID 4909888.

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