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| Formula | C16H23NO |
| Molar mass | 245.366 g·mol−1 |
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α-Pyrrolidinoisohexanophenone (mainly known asA-PiHP orα-PiHP) is astimulant drug of thecathinone class that has been sold online as adesigner drug. It acts as a potentnorepinephrine-dopamine reuptake inhibitor (NDRI). In July 2016 α-PiHP was first identified as a designer drug[2] when it was reported to theEMCDDA by a forensic laboratory in Slovenia.[3][4] It is a positional isomer of pyrovalerone, with the methyl group shifted from the 4-position of the aromatic ring to the 4-position of the acyl chain. Similarly to other cathinones, use of α-PiHP can result in compulsive redosing, addiction, anxiety, paranoia, and psychosis.
In a classic 2006 study of pyrrolidinyl cathinone derivatives by Meltzer et al. atOrganix, the alpha-isobutyl derivative of pyrovalerone, O-2494, was found to have the highest potencyin vitro as aninhibitor of thedopamine transporter of the alpha substituted derivatives tested.[5] Compared to α-PVP and α-PHP, α-PiHP displays a higher selectivity for the dopamine transporter.
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