Class of enzymes
UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC4.2.1.115,FlaA1,UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase,PseB,UDP-N-acetylglucosamine hydro-lyase (inverting,UDP-2-acetamido-2,6-dideoxy-β-L)arabino-hex-4-ulose-forming)) is anenzyme withsystematic nameUDP-N-acetyl-α-D-glucosamine hydro-lyase (inverting; UDP-2-acetamido-2,6-dideoxy-β-L-arabino-hex-4-ulose-forming).[1][2][3] This enzymecatalyses the followingchemical reaction
- UDP-N-acetyl-α-D-glucosamine
UDP-2-acetamido-2,6-dideoxy-β-L-arabino-hex-4-ulose + H2O
This enzyme contains NADP+ as a cofactor.
- ^Ishiyama N, Creuzenet C, Miller WL, Demendi M, Anderson EM, Harauz G, Lam JS, Berghuis AM (August 2006)."Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity".The Journal of Biological Chemistry.281 (34):24489–95.doi:10.1074/jbc.m602393200.PMID 16651261.
- ^Schirm M, Soo EC, Aubry AJ, Austin J, Thibault P, Logan SM (June 2003)."Structural, genetic and functional characterization of the flagellin glycosylation process in Helicobacter pylori".Molecular Microbiology.48 (6):1579–92.doi:10.1046/j.1365-2958.2003.03527.x.PMID 12791140.
- ^Schoenhofen IC, McNally DJ, Brisson JR, Logan SM (September 2006)."Elucidation of the CMP-pseudaminic acid pathway in Helicobacter pylori: synthesis from UDP-N-acetylglucosamine by a single enzymatic reaction".Glycobiology.16 (9):8C–14C.doi:10.1093/glycob/cwl010.PMID 16751642.
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