Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Tinyatoxin

From Wikipedia, the free encyclopedia
Tinyatoxin
Names
Preferred IUPAC name
[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-Benzyl-6a-hydroxy-8,10-dimethyl-7-oxo-11a-(prop-1-en-2-yl)-3a,3b,6,6a,7,9a,11,11a-octahydro-2H,10H-2,9b-epoxyazuleno[5,4-e][1,3]benzodioxol-5-yl]methyl (4-hydroxyphenyl)acetate
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard100.165.094Edit this at Wikidata
MeSHtinyatoxin
UNII
  • InChI=1S/C36H38O8/c1-21(2)34-17-23(4)36-28(32(34)42-35(43-34,44-36)19-25-8-6-5-7-9-25)15-26(18-33(40)29(36)14-22(3)31(33)39)20-41-30(38)16-24-10-12-27(37)13-11-24/h5-15,23,28-29,32,37,40H,1,16-20H2,2-4H3/t23-,28+,29-,32-,33-,34-,35-,36-/m1/s1
    Key: WWZMXEIBZCEIFB-ACAXUWNGSA-N
  • C[C@@H]1C[C@]2([C@H]3[C@H]4[C@]1([C@@H]5C=C(C(=O)[C@]5(CC(=C4)COC(=O)Cc6ccc(cc6)O)O)C)O[C@](O3)(O2)Cc7ccccc7)C(=C)C
Properties
C36H38O8
Molar mass598.692 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)
Chemical compound
Tinyatoxin
HeatAbove peak
Scoville scale5,300,000,000 SHU

Tinyatoxin (TTX orTTN) is an analog of the neurotoxinresiniferatoxin. It occurs naturally inEuphorbia poissonii.[1]

It is a neurotoxin that acts via full agonism of thevanilloid receptors of sensory nerves.[2] Tinyatoxin has a potential for pharmaceutical uses similar to uses ofcapsaicin. Tinyatoxin is about one third as strong asresiniferatoxin but is still an ultrapotent analogue of capsaicin, with a heat intensity estimate of 300 to 350 times that of capsaicin.[citation needed]

References

[edit]
  1. ^Euphorbia poissonii in BoDD – Botanical Dermatology Database
  2. ^Szallasi, A. & Blumberg, P.M. (1991). "Characterization of vanilloid receptors in the dorsal horn of pig spinal cord".Brain Res.547 (2):335–338.doi:10.1016/0006-8993(91)90982-2.PMID 1884211.S2CID 25052101.


TRPA
Activators
Blockers
TRPC
Activators
Blockers
TRPM
Activators
Blockers
TRPML
Activators
Blockers
TRPP
Activators
Blockers
TRPV
Activators
Blockers


Stub icon

This article about anorganic compound is astub. You can help Wikipedia byadding missing information.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Tinyatoxin&oldid=1312019869"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2026 Movatter.jp