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| Clinical data | |
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| Trade names | Tindamax, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a604036 |
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| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Protein binding | 12% |
| Metabolism | Liver (CYP3A4) |
| Eliminationhalf-life | 12–14 hours |
| Excretion | Urine (20–25%), feces (12%) |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.039.089 |
| Chemical and physical data | |
| Formula | C8H13N3O4S |
| Molar mass | 247.27 g·mol−1 |
| 3D model (JSmol) | |
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Tinidazole, sold under the brand nameTindamax among others, is a medication used against infections caused by certainanaerobicbacteria andprotozoa. It was developed in 1972 and is a prominent member of thenitroimidazoleantibiotic class.[2]
Tinidazole is a therapeutic alternative on theWorld Health Organization's List of Essential Medicines.[3]
Tinidazole is a narrow spectrum antimicrobial drug used to treat infections caused byHelicobacter pylori,Entamoeba histolytica,Giardia spp. andTrichomonas vaginalis.[4]
Drinking alcohol while taking tinidazole causes an unpleasantdisulfiram-like reaction, which includes nausea, vomiting, headache, increased blood pressure, flushing, and shortness of breath.[medical citation needed]
Elimination half-life is 13.2 ± 1.4 hours. Plasma half-life is 12 to 14 hours.[medical citation needed]
Tinidazole was approved for medical treatment in the United States in 2004.[1][5]
