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Tetramer

From Wikipedia, the free encyclopedia
Oligomer formed from four monomers or subunits
An example of asubunit, humanhemoglobin. The protein'sα andβ subunits are coloured red and blue.

Atetramer (/ˈtɛtrəmər/) (tetra-, "four" +-mer, "parts") is anoligomer formed from fourmonomers orsubunits. The associated property is calledtetramery. An example frominorganic chemistry istitanium methoxide with theempirical formula Ti(OCH3)4, which is tetrameric in solid state and has themolecular formula Ti4(OCH3)16.[1] An example fromorganic chemistry iskobophenol A, a substance that is formed by combining four molecules ofresveratrol.[2][3]

In biochemistry, it similarly refers to a biomolecule formed of four units, that are the same (homotetramer), i.e. as inConcanavalin A or different (heterotetramer), i.e. as inhemoglobin. Hemoglobin has 4 similar sub-units whileimmunoglobulins have 2 very different sub-units. The different sub-units may have each their own activity, such as bindingbiotin inavidin tetramers, or have a common biological property, such as theallosteric binding ofoxygen in hemoglobin.

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References

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  1. ^Wright, D. A.; Williams, D. A. (1968)."The crystal and molecular structure of titanium tetramethoxide".Acta Crystallogr. B.24 (8):1107–1114.doi:10.1107/S0567740868003766.
  2. ^Shu, Na; Zhou, Hong; Hu, Changqi (2006)."Simultaneous determination of the contents of three stilbene oligomers inCaragana sinica collected in different seasons using an improved HPLC method".Biol. Pharm. Bull.29 (4):608–612.doi:10.1248/bpb.29.608.PMID 16595888.
  3. ^Li, Liya; Henry, Geneive E.; Seeram, Navindra P. (2009). "Identification and bioactivities of resveratrol oligomers and flavonoids fromCarex folliculata seeds".J. Agric. Food Chem.57 (16):7282–7287.doi:10.1021/jf901716j.PMID 19627089.
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