Movatterモバイル変換

Streptogramin

From Wikipedia, the free encyclopedia

Class of antibiotics

Streptogramins are a class of antibiotics. They work as protein synthesis inhibitors.^[1]

Streptogramins are effective in the treatment ofvancomycin-resistantStaphylococcus aureus (VRSA) andvancomycin-resistantEnterococcus (VRE), two of the most rapidly growing strains ofmultidrug-resistant bacteria. They fall into two groups:streptogramin A (23-memberedmacrolide) andstreptogramin B (depsipeptide). The two groups act synergistically. They are naturally produced in a 3:7 ratio; most formulations keep this ratio.^[2]

Members include:

Quinupristin/dalfopristin, made by chemically modifying pristinamycin (semisynthesis)
Pristinamycin, made byStreptomyces pristinaespiralis
Virginiamycin, made byStreptomyces virginiae and others
Linopristin/flopristin, made by semisynthesis. experimental streptogramin in clinical trials for the treatment ofrespiratory tractinfections.^[3]
Etamycin, a streptogramin B.^[4]

^"Antimicrobial Chemotherapy". University of Leeds. Archived fromthe original on 2007-04-28.
^Aronson J, ed. (2016)."Streptogramins".Meyler's Side Effects of Drugs. p. 499.doi:10.1016/B978-0-444-53717-1.01472-4.ISBN 978-0-444-53716-4.Streptogramins [1] are a class of antibiotics of two types, streptogramin A and streptogramin B. Separately, group A and group B streptogramins are bacteriostatic, by reversible binding to the 50S subunit of 70S bacterial ribosomes. Together, however, streptogramins from each group are synergic and bactericidal.
^Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, et al. (January 2009). "Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America".Clinical Infectious Diseases.48 (1):1–12.doi:10.1086/595011.PMID 19035777.
^Haste NM, Perera VR, Maloney KN, Tran DN, Jensen P, Fenical W, et al. (May 2010)."Activity of the streptogramin antibiotic etamycin against methicillin-resistant Staphylococcus aureus".The Journal of Antibiotics.63 (5):219–224.doi:10.1038/ja.2010.22.PMC 2889693.PMID 20339399.

De Simeis D, Serra S (April 2021)."Actinomycetes: A Never-Ending Source of Bioactive Compounds-An Overview on Antibiotics Production".Antibiotics.10 (5): 483.doi:10.3390/antibiotics10050483.PMC 8143475.PMID 33922100.
Mukhtar TA, Wright GD (February 2005). "Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis".Chemical Reviews.105 (2):529–542.Bibcode:2005ChRv..105..529M.doi:10.1021/cr030110z.PMID 15700955.

-mycin (Streptomyces)	Streptomycin^# Dihydrostreptomycin Neomycin^# Framycetin Paromomycin^# Ribostamycin Kanamycin Amikacin^# Arbekacin Bekanamycin Dibekacin Tobramycin (+loteprednol) Spectinomycin^# Hygromycin B Totomycin Apramycin Nourseothricin
-micin (Micromonospora)	Gentamicin^# Netilmicin Sisomicin Micronomicin Plazomicin^# Isepamicin Verdamicin Astromicin
other	Butirosin

Tetracyclines	Doxycycline^# Chlortetracycline Clomocycline Demeclocycline Eravacycline Lymecycline Meclocycline^‡ Metacycline Minocycline Omadacycline Oxytetracycline Penimepicycline Rolitetracycline Sarecycline Tetracycline^#
Glycylcyclines	Tigecycline

Amphenicols	Chloramphenicol^# Azidamfenicol Thiamphenicol Florfenicol

Macrolides	Boromycin Carbomycin Carrimycin Clarithromycin^# Dirithromycin Erythromycin^# Flurithromycin Josamycin Kitasamycin Midecamycin Miocamycin Nafithromycin Oleandomycin Rokitamycin Roxithromycin Spiramycin Tildipirosin Tilmicosin Troleandomycin Tylosin Tylvalosin
Azalides	Azithromycin^# Gamithromycin Tulathromycin
Ketolides	Telithromycin^‡ Cethromycin Solithromycin^†
Lincosamides	Clindamycin^# Lincomycin Pirlimycin
Oxepanoprolinamides	Cresomycin Iboxamycin
Streptogramins	Pristinamycin (IA,IIA,IIB) NXL103 (Flopristin,Linopristin) Quinupristin/dalfopristin (Dalfopristin,Quinupristin) Streptogramin A Streptogramin B Virginiamycin (S1)

This systemicantibiotic-related article is astub. You can help Wikipedia byadding missing information.

Hidden categories: