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{{#invoke:navbox|navbox | name = Ion channel modulators | title = [[Channel modulator|Ion channel modulator]]s | state = {{{state<includeonly>|collapsed</includeonly>}}} | listclass = hlist | groupstyle = text-align:center; | group1 = [[Calcium channel|Calcium]] | list1 = {{#invoke:navbox|navbox|child | groupstyle = text-align:center; | groupwidth = 5em;   | group1 = {{abbrlink|VDCCs|Voltage-dependent calcium channels}}   | list1 = {{#invoke:navbox|navbox|child   | groupstyle = text-align:center;   | groupwidth = 5em;     | group1 = [[Calcium channel blocker|Blocker]]s     | list1 =* '''[[L-type calcium channel|L-type-selective]]:''' ''[[Dihydropyridine]]s:'' [[Amlodipine]] ([[Telmisartan/amlodipine/indapamide|+telmisartan and indapamide]])* [[Aranidipine]]* [[Azelnidipine]]* [[Barnidipine]]* [[Clevidipine]]* [[Cronidipine]]* [[Darodipine]]* [[Dexniguldipine]]* [[Elgodipine]]* [[Elnadipine]]* [[Felodipine]]* [[Flordipine]]* [[Furnidipine]]* [[Iganidipine]]* [[Isradipine]]* [[Lacidipine]]* [[Lemildipine]]* [[Lercanidipine]]* [[Levamlodipine]]* [[Levniguldipine]]* [[Manidipine]]* [[Barnidipine|Mepirodipine]]* [[Mesudipine]]* [[Nicardipine]]* [[Nifedipine]]* [[Niguldipine]]* [[Niludipine]]* [[Nilvadipine]]* [[Nimodipine]]* [[Nisoldipine]]* [[Nitrendipine]]* [[Olradipine]]* [[Oxodipine]]* [[Palonidipine]]* [[Pranidipine]]* [[Riodipine|Ryodipine (riodipine)]]* [[Sagandipine]]* [[Sornidipine]]* [[Teludipine]]* [[Tiamdipine]]* [[Trombodipine]]* [[Vatanidipine]]; ''[[Diltiazem]] derivatives:'' [[Clentiazem]]* [[Diltiazem]]* [[Iprotiazem]]* [[Nictiazem]]* [[Siratiazem]]; ''[[Arylalkylamine|Phenylalkylamine]]s:'' [[Anipamil]]* [[Dagapamil]]* [[Devapamil]]* [[Dexverapamil]]* [[Emopamil]]* [[Etripamil]]* [[Falipamil]]* [[Gallopamil]]* [[Levemopamil]]* [[Nexopamil]]* [[Norverapamil]]* [[Ronipamil]]* [[Tiapamil]]* [[Verapamil]]; ''Others:'' [[AH-1058]]* [[Brinazarone]]* [[Budiodarone]]* [[Celivarone]]* [[Cyproheptadine]]* [[Dronedarone]]* [[Fantofarone]]* [[SR-33805]]<!--allosteric blocker-->* [[Tetrahydropalmatine]]* '''[[N-type calcium channel|N-type-selective]]:''' [[ω-Conotoxin]]s* [[ω-Conotoxin GVIA]]* [[Caroverine]]* [[Huwentoxin XVI]]* [[Leconotide|Leconotide (ω-conotoxin CVID)]]* [[PD-173212]]* [[Ralfinamide]]* [[Safinamide]]* [[Z160]]* [[Ziconotide|Ziconotide (ω-conotoxin MVIIA)]]* '''[[P-type calcium channel|P-type-selective]]:''' [[ω-Agatoxin IVA]]* [[ω-Agatoxin IVB]]* '''[[R-type calcium channel|R-type-selective]]:''' [[SNX-482]]* '''[[T-type calcium channel|T-type-selective]]:''' [[ABT-639]]<!--Cav3.2-selective-->* [[ML-218]]* [[Niflumic acid]]* [[NNC 55-0396]]* [[ProTx I]]<!--Cav3.1-selective-->* [[Z944]]* [[Zonisamide]]* '''Non-selective:''' [[ω-Agatoxin TK]]<!--dual P/Q-type blocker-->* [[ω-Conotoxin MVIIC]]<!--triple N/P/Q-type blocker-->* [[Benidipine]]<!--triple L/N/T-type blocker-->* [[Bepridil]]<!--dual L/T-type blocker-->* [[Cilnidipine]]<!--dual L/N-type blocker-->* [[Cinnarizine]]* [[Dotarizine]]* [[Efonidipine]]<!--dual L/T-type blocker-->* [[Flunarizine]]* [[Lamotrigine]]<!--triple L/N/P-type blocker-->* [[Levetiracetam]]<!--triple N/P/Q-type blocker-->* [[Lomerizine]]<!--dual L/T-type blocker-->* [[Loperamide]]<!--dual L/N-type blocker-->* [[Mibefradil]]<!--dual L/T-type blocker-->* [[NP078585]]<!--dual N/T-type blocker-->* [[Ruthenium red]]<!--dual N/P-type blocker-->* [[TROX-1]]<!--quadruple N/P/Q/R-type blocker-->* '''[[Voltage-dependent calcium channel#α2δ Subunit|α<sub>2</sub>δ subunit]]-selective ([[gabapentinoid]]s):''' [[4-Methylpregabalin]]* [[Arbaclofen]]<!--Weakly-->* [[Arbaclofen placarbil]]<!--Weakly-->* [[Atagabalin]]* [[Baclofen]]<!--Weakly-->* [[Gabapentin]]* [[Gabapentin enacarbil]]* [[Imagabalin]]* [[Mirogabalin]]* [[PD-200,347]]* [[PD-217,014]]* [[PD-299,685]]* [[Phenibut]]* [[Pregabalin]]* '''Others/unsorted:''' [[Bencyclane]]* [[Berbamine]]* [[Bevantolol]]* [[Canadine]]* [[Carboxyamidotriazole]]* [[Cycleanine]]* [[Dauricine]]* [[Dimeditiapramine]]* [[Diproteverine]]* [[Enpiperate]]* [[Eperisone]]* [[Elpetrigine]]* [[Ethadione]]* [[Alcohol (drug)|Ethanol (alcohol)]]* [[Ethosuximide]]* [[Fasudil]]* [[Fendiline]]* [[Fostedil]]* [[Imepitoin]]* [[JTV-519]]* [[Lidoflazine]]* [[Magnesium]]* [[Manoalide]]* [[Mesuximide]]* [[Monatepil]]* [[Naftopidil]]* [[Ochratoxin A]]* [[Osthol]]* [[Otilonium bromide]]* [[Paramethadione]]* [[Phensuximide]]* [[Pinaverium bromide]]* [[Prenylamine]]* [[Rhynchophylline]]* [[Sesamodil]]* [[Silperisone]]* [[Sipatrigine]]* [[Terodiline]]* [[Tetrandrine]]* [[Tolperisone]]* [[Trimethadione]]* [[Valperinol]]   | group2 = [[Calcium channel opener|Activator]]s   | list2 =* '''[[L-type calcium channel|L-type-selective]]:''' [[Bay K8644]]    }}}} | group2 = [[Potassium channel|Potassium]] | list2 = {{#invoke:navbox|navbox|child | groupstyle = text-align:center; | groupwidth = 5em;   | group1 = {{abbrlink|VGKCs|Voltage-gated potassium channels}}   | list1 = {{#invoke:navbox|navbox|child   | groupstyle = text-align:center;   | groupwidth = 5em;     | group1 = [[Potassium channel blocker|Blocker]]s     | list1 =* [[3,4-Diaminopyridine|3,4-Diaminopyridine (amifampridine)]]* [[4-Aminopyridine|4-Aminopyridine (fampridine/dalfampridine)]]* [[Adekalant]]* [[Almokalant]]* [[Amiodarone]]* [[Azimilide]]* [[Bretylium]]* [[Bunaftine]]* [[Charybdotoxin]]* [[Clamikalant]]* [[Conotoxin]]s* [[Dalazatide]]<!--Kv1.3-selective-->* [[Dendrotoxin]]* [[Dofetilide]]* [[Dronedarone]]* [[E-4031]]* [[Hanatoxin]]* [[HgeTx1]]* [[HsTx1]]* [[Ibutilide]]* [[Inakalant]]* [[Kaliotoxin]]* [[Linopirdine]]* [[Lolitrem B]]* [[Maurotoxin]]* [[Nifekalant]]* [[Notoxin]]* [[Paxilline]]* [[Pinokalant]]* [[Quinidine]]* [[ShK-186]]<!--Kv1.3-selective-->* [[Sotalol]]* [[Tedisamil]]* [[Terikalant]]* [[Tetraethylammonium]]* [[Vernakalant]]* '''[[hERG]] (KCNH2, K<sub>v</sub>11.1)-specific:''' [[Ajmaline]]* [[Amiodarone]]* [[AmmTX3]]* [[Astemizole]]* [[Azaspiracid]]* [[AZD1305]]* [[Azimilide]]* [[Bedaquiline]]* [[BeKm-1 toxin|BeKm-1]]* [[BmTx3]]* [[BRL-32872]]* [[Chlorpromazine]]* [[Cisapride]]* [[Clarithromycin]]* [[Darifenacin]]* [[Dextropropoxyphene]]* [[Diallyl trisulfide]]* [[Domperidone]]* [[E-4031]]* [[Ergtoxin]]s* [[Erythromycin]]* [[Gigactonine]]* [[Haloperidol]]* [[Ketoconazole]]* [[Norpropoxyphene]]* [[Orphenadrine]]* [[Pimozide]]* [[PNU-282,987]]* [[Promethazine]]* [[Quinidine]]* [[Ranolazine]]* [[Roxithromycin]]* [[Sertindole]]* [[Solifenacin]]* [[Tamulotoxin]]* [[Terodiline]]* [[Terfenadine]]* [[Thioridazine]]* [[Tolterodine]]* [[Vanoxerine]]* [[Vernakalant]]* '''[[KCNQ|KCNQ (K<sub>v</sub>7)]]-specific:''' [[Linopirdine]]* [[XE-991]]* [[Ssm spooky toxin|Spooky toxin (SsTx)]]     | group2 = [[Potassium channel opener|Activator]]s     | list2 =* '''[[KCNQ|KCNQ (K<sub>v</sub>7)]]-specific:''' [[Flupirtine]]* [[Retigabine]]    }}   | group2 = {{abbrlink|IRKs|Inwardly rectifying potassium channel}}   | list2 = {{#invoke:navbox|navbox|child   | groupstyle = text-align:center;   | groupwidth = 5em;     | group1 = [[Potassium channel blocker|Blocker]]s     | list1 =* '''{{abbrlink|K<sub>ATP</sub>|ATP-sensitive potassium channel}}-specific:''' [[Acetohexamide]]* [[Carbutamide]]* [[Chlorpropamide]]* [[Glibenclamide|Glibenclamide (glyburide)]]* [[Glibornuride]]* [[Glicaramide]]* [[Gliclazide]]* [[Glimepiride]]* [[Glipizide]]* [[Gliquidone]]* [[Glisoxepide]]* [[Glyclopyramide]]* [[Glycyclamide]]* [[Metahexamide]]* [[Mitiglinide]]* [[Nateglinide]]* [[Repaglinide]]* [[Tolazamide]]* [[Tolbutamide]]* '''{{abbrlink|GIRK|G protein-coupled inwardly rectifying potassium channel}}-specific:''' [[Barium]]* [[Caramiphen]]* [[Cloperastine]]* [[Clozapine]]* [[Dextromethorphan]]* [[Ethosuximide]]* [[Ifenprodil]]* [[Tertiapin]]* [[Tipepidine]]     | group2 = [[Potassium channel opener|Activator]]s     | list2 =* '''{{abbrlink|K<sub>ATP</sub>|ATP-sensitive potassium channel}}-specific:''' [[Aprikalim]]* [[Bimakalim]]* [[Cromakalim]]* [[Diazoxide]]* [[Emakalim]]* [[Levcromakalim]]* [[Mazokalim]]* [[Minoxidil]]* [[Minoxidil sulfate]]* [[Naminidil]]* [[Nicorandil]]* [[Pinacidil]]* [[Rilmakalim]]* [[Sarakalim]]* '''{{abbrlink|GIRK|G protein-coupled inwardly rectifying potassium channel}}-specific:''' [[ML-297|ML-297 (VU0456810)]]   }}   | group3 = {{abbrlink|K<sub>Ca</sub>|Calcium-activated potassium channel}}   | list3 = {{#invoke:navbox|navbox|child   | groupstyle = text-align:center;   | groupwidth = 5em;     | group1 = [[Potassium channel blocker|Blocker]]s     | list1 =* '''[[BK channel|BK<sub>Ca</sub>]]-specific:''' [[Alcohol (drug)|Ethanol (alcohol)]]* [[GAL-021]]     | group2 = [[Potassium channel opener|Activator]]s     | list2 =* '''[[BK channel|BK<sub>Ca</sub>]]-specific:''' [[Flufenamic acid]]* [[Meclofenamic acid]]* [[Niflumic acid]]* [[Nimesulide]]* [[Rottlerin|Rottlerin (mallotoxin)]]* [[Tolfenamic acid]]   }}   | group4 = {{abbrlink|K2Ps|Tandem pore domain potassium channel}}   | list4 = {{#invoke:navbox|navbox|child   | groupstyle = text-align:center;   | groupwidth = 5em;     | group1 = [[Potassium channel blocker|Blocker]]s     | list1 =* [[12-O-Tetradecanoylphorbol-13-acetate]]* [[Arachidonic acid]]* [[Fluoxetine]]* [[Norfluoxetine]]     | group2 = [[Potassium channel opener|Activator]]s     | list2 =* [[Riluzole]]   }}}} | group3 = [[Sodium channel|Sodium]] | list3 = {{#invoke:navbox|navbox|child | groupstyle = text-align:center; | groupwidth = 5em;   | group1 = {{abbrlink|VGSCs|Voltage-gated sodium channels}}   | list1 = {{#invoke:navbox|navbox|child   | groupstyle = text-align:center;   | groupwidth = 5em;     | group1 = [[Sodium channel blocker|Blocker]]s     | list1 =* ''Antianginals:'' [[Ranolazine]]* ''Antiarrhythmics (class I):'' [[Ajmaline]]* [[Aprindine]]* [[Disopyramide]]* [[Dronedarone]]* [[Encainide]]* [[Flecainide]]* [[Lidocaine]]* [[Lorajmine]]* [[Lorcainide]]* [[Mexiletine]]* [[Moracizine|Moricizine]]* [[Pilsicainide]]* [[Prajmaline]]* [[Procainamide]]* [[Propafenone]]* [[Quinidine]]* [[Sparteine]]* [[Tocainide]]* ''Anticonvulsants:'' [[Acetylpheneturide]]* [[Carbamazepine]]* [[Cenobamate]]* [[Chlorphenacemide]]* [[Elpetrigine]]* [[Eslicarbazepine acetate]]* [[Ethotoin]]* [[Fosphenytoin]]* [[Lamotrigine]]* [[Lacosamide]]* [[Licarbazepine]]* [[Mephenytoin]]* [[Oxcarbazepine]]* [[Oxitriptyline]]* [[Phenacemide]]* [[Pheneturide]]* [[Phenytoin]]* [[Rufinamide]]* [[Sipatrigine]]* [[Topiramate]]* [[Sodium valproate]]* [[Valnoctamide]]* [[Valproate pivoxil]]* [[Valproate semisodium]]* [[Valproic acid]]* [[Valpromide]]* [[Zonisamide]]* ''Local anesthetics:'' [[3-(p-Fluorobenzoyloxy)tropane|''p''FBT]]* [[Amylocaine]]* [[Articaine]]* [[Benzocaine]]* [[Bupivacaine]] ([[Levobupivacaine]], [[Ropivacaine]])* [[Butacaine]]* [[Butamben]]* [[Chloroprocaine]]* [[Cinchocaine]]* [[Cocaine]]* [[Cyclomethycaine]]* [[Dimethocaine]]* [[Diphenhydramine]]* [[Etidocaine]]* [[Hexylcaine]]* [[Iontocaine]]* [[Lidocaine]]* [[Mepivacaine]]* [[Meprylcaine]]* [[Metabutoxycaine]]* [[Orthocaine]]* [[Piperocaine]]* [[Prilocaine]]* [[Procaine]]* [[Propoxycaine]]* [[Proxymetacaine]]* [[Risocaine]]* [[Tetracaine]]* [[Trimecaine]]* ''Analgesics:'' [[AZD-3161]]* [[DSP-2230]]* [[Funapide]]* [[GDC-0276]]* [[NKTR-171]]* [[PF-04531083]]* [[PF-05089771]]* [[Ralfinamide]]* [[Raxatrigine]]* [[RG7893|RG7893 (GDC-0287)]]* [[Suzetrigine]]* ''Toxins:'' [[Conotoxin]]s* [[Neosaxitoxin]]* [[Saxitoxin]]* [[Tetrodotoxin]]* [[Zetekitoxin AB]]* ''Others:'' [[Buprenorphine]]* [[Evenamide]]* [[Menthol]] ([[Mentha|mint]])* [[Safinamide]]* [[Tricyclic antidepressant]]s   | group2 = [[Sodium channel opener|Activator]]s   | list2 =* [[Aconitine]]* Atracotoxins ([[omega-Atracotoxin|ω-Atracotoxin]], [[Robustoxin]], [[Versutoxin]])* [[Batrachotoxin]]* [[Ciguatoxin]]s* [[Grayanotoxin]]s* [[Poneratoxin]]   }}   | group2 = {{abbrlink|ENaC|Epithelial sodium channel}}   | list2 = {{#invoke:navbox|navbox|child   | groupstyle = text-align:center;   | groupwidth = 5em;     | group1 = [[Sodium channel blocker|Blocker]]s     | list1 =* [[Amiloride]]* [[Benzamil]]* [[Triamterene]]     | group2 = [[Sodium channel opener|Activator]]s     | list2 =* [[Solnatide]]   }}   | group3 = {{abbrlink|ASICs|Acid-sensing ion channel}}   | list3 = {{#invoke:navbox|navbox|child   | groupstyle = text-align:center;   | groupwidth = 5em;     | group1 = [[Sodium channel blocker|Blocker]]s     | list1 =* [[A-317567]]* [[Amiloride]]* [[Aspirin]]* [[Ibuprofen]]* [[PcTX1]]     | group2 = [[Sodium channel opener|Activator]]s     | list2 =  }}}} | group4 = [[Chloride channel|Chloride]] | list4 = {{#invoke:navbox|navbox|child | groupstyle = text-align:center; | groupwidth = 5em;   | group1 ={{abbrlink|CaCCs|Calcium-activated chloride channel}}   | list1 = {{#invoke:navbox|navbox|child   | groupstyle = text-align:center;   | groupwidth = 5em;     | group1 = [[Chloride channel blocker|Blocker]]s     | list1 =* [[Crofelemer]]<!--ANO1-->* [[DIDS]]<!--ANO1-->* [[Ethacrynic acid]]* [[Flufenamic acid]]* [[Fluoxetine]]* [[Furosemide]]* [[Glibenclamide]]* [[Mefloquine]]* [[Mibefradil]]* [[Niflumic acid]]     | group2 = [[Chloride channel opener|Activator]]s     | list2 =* [[Carbachol]]<!--ANO1-->   }}   | group2 = {{abbrlink|CFTR|Cystic fibrosis transmembrane conductance regulator}}   | list2 = {{#invoke:navbox|navbox|child   | groupstyle = text-align:center;   | groupwidth = 5em;     | group1 = [[Chloride channel blocker|Blocker]]s     | list1 =* [[Glibenclamide]]* [[Lonidamine]]* [[Piretanide]]     | group2 = [[Chloride channel opener|Activator]]s     | list2 =* [[1,7-Phenanthroline]]* [[1,10-Phenanthroline]]* [[4,7-Phenanthroline]]* [[7,8-Benzoquinoline]]* [[Ivacaftor]]* [[Phenanthridine]]   }}   | group3 = Unsorted   | list3 = {{#invoke:navbox|navbox|child   | groupstyle = text-align:center;   | groupwidth = 5em;     | group1 = [[Chloride channel blocker|Blocker]]s     | list1 =* [[Bumetanide]]* [[Flufenamic acid]]* [[Meclofenamic acid]]* [[Mefenamic acid]]* [[Mepacrine]]* [[Niflumic acid]]* [[Talniflumate]]* [[Tolfenamic acid]]* [[Trifluoperazine]]     | group2 = [[Chloride channel opener|Activator]]s     | list2 =   }} }} | group5 = Others | list5 = {{#invoke:navbox|navbox|child | groupstyle = text-align:center; | groupwidth = 5em;   | group1 = {{abbrlink|TRPs|Transient receptor potential channels}}   | list1 = * See [[Template:Transient receptor potential channel modulators|here]] instead.   | group2 = {{abbrlink|LGICs|Ligand gated ion channels}}   | list2 = * See [[Template:Pharmacomodulation|here]] instead. }} | below = '''''See also:''' [[Template:Receptor modulators|Receptor/signaling modulators]] • [[Template:Transient receptor potential channel modulators|Transient receptor potential channel modulators]]''}}<noinclude>{{collapsible option}}[[Category:Drug templates by receptor, channel, or pump]]</noinclude>

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