LexA binds to an SOS box in the absence ofDNA damage. In the presence of DNA damage the binding ofLexA is inactivated by theRecAactivator. SOS boxes differ in DNA sequences and binding affinity towardsLexA from organism to organism.[2] Furthermore, SOS boxes may be present in a dual fashion, which indicates that more than one SOS box can be within the same promoter.[3]
^Henkin, Tina M.; Peters, Joseph E. (2020).Snyder and Champness molecular genetics of bacteria (Fifth ed.). Hoboken, NJ : Washington, D.C: John Wiley & Sons, Inc. p. 409.ISBN9781555819750.
^Walker, Graham C. (October 1995). "SOS-regulated proteins in translesion DNA synthesis and mutagenesis".Trends in Biochemical Sciences.20 (10):416–20.doi:10.1016/s0968-0004(00)89091-x.PMID8533155.
^Tapias, A.; Barbé, J. (August 1999). "Regulation of divergent transcription from the uvrA-ssb promoters inSinorhizobium meliloti".Molecular and General Genetics MGG.262 (1):121–130.doi:10.1007/s004380051066.PMID10503543.S2CID2373618.
^Mazón, G.; Lucena, J. M.; Campoy, S.; Fernández de Henestrosa, A. R.; Candau, P.; Barbé, J. (February 2004). "LexA-binding sequences in Gram-positive and cyanobacteria are closely related".Molecular Genetics and Genomics.271 (1):40–49.doi:10.1007/s00438-003-0952-x.PMID14652736.S2CID9219764.
