SLC45A4 is a member of the SLC45 family ofsolute carriers. Analysis of theprotein function in a recombinantyeast expression assay show that it can: (i) transport adisaccharide,sucrose, as well simple sugars such asglucose andfructose (ii) perform secondary active transport in a proton-dependent manner.[5]
It is associated with sugar transport in thespermatozoa.[6] Additionally, it has been identified as a necessary component in thecell death caused of the compoundparaquat.[7]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Bartölke R, Heinisch JJ, Wieczorek H, Vitavska O (December 2014). "Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae".The Biochemical Journal.464 (2):193–201.doi:10.1042/BJ20140572.PMID25164149.
