SLC45A1 is a member of the SLC45 family ofsolute carriers. Analysis of the protein function in a recombinant yeast expression assay show that it can:(i) transport a disaccharide, such as glucose and sucrose(ii) perform secondary active transport in a proton-dependent manner.[5]
It is associated with sugar transport in the brain, and rare mutations in the gene are associated with intellectual disability and epilepsy.[6] analogous to the effect of mutation of the cerebral glucose transporterGLUT1(SLC2A1).
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Bartölke R, Heinisch JJ, Wieczorek H, Vitavska O (December 2014). "Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae".The Biochemical Journal.464 (2):193–201.doi:10.1042/BJ20140572.PMID25164149.
