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SLC27A2

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
SLC27A2
Identifiers
AliasesSLC27A2, ACSVL1, FACVL1, FATP2, HsT17226, VLACS, VLCS, hFACVL1, solute carrier family 27 member 2
External IDsOMIM:603247;MGI:1347099;HomoloGene:37830;GeneCards:SLC27A2;OMA:SLC27A2 - orthologs
EC number6.2.1.3
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for SLC27A2
Genomic location for SLC27A2
Band15q21.2Start50,182,196bp[1]
End50,236,385bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SLC27A2
Genomic location for SLC27A2
Band2|2 F1Start126,394,327bp[2]
End126,430,163bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • liver

  • right lobe of liver

  • kidney tubule

  • corpus epididymis

  • mucosa of transverse colon

  • caput epididymis

  • mucosa of paranasal sinus

  • glomerulus

  • metanephric glomerulus
Top expressed in
  • right kidney

  • proximal tubule

  • human kidney

  • left lobe of liver

  • saccule

  • olfactory epithelium

  • parotid gland

  • Paneth cell

  • gallbladder

  • lacrimal gland
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11001

26458

Ensembl

ENSG00000140284

ENSMUSG00000027359

UniProt

O14975

O35488

RefSeq (mRNA)

NM_003645
NM_001159629

NM_011978

RefSeq (protein)

NP_001153101
NP_003636

NP_036108

Location (UCSC)Chr 15: 50.18 – 50.24 MbChr 2: 126.39 – 126.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Long-chain fatty acid transport protein 2 is anenzyme that in humans is encoded by theSLC27A2gene.[5][6]

The protein encoded by this gene is anisozyme oflong-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids intofatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain andvery long chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney and is present in bothendoplasmic reticulum andperoxisomes but not inmitochondria. Its decreased peroxisomal enzyme activity is in part responsible for thebiochemical pathology in X-linkedadrenoleukodystrophy.[6]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000140284 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000027359 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Wakui K, Aoyama T, Uchiyama A, Hashimoto T, Fukushima Y (Oct 1998). "Assignment of human fatty-acid-coenzyme A ligase, very long-chain 1 gene (FACVL1) to human chromosome band 15q21.2 by fluorescence in situ hybridization".Cytogenet Cell Genet.81 (3–4):292–3.doi:10.1159/000015051.PMID 9730624.S2CID 46774274.
  6. ^ab"Entrez Gene: SLC27A2 solute carrier family 27 (fatty acid transporter), member 2".

Further reading

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

By group
SLC1–10
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SLC11–20
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SLC21–30
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SLC31–40
(31):
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SLC41–48
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SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)
Enzymes
Transporters
Structure/Peroxin
LAMP
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