| Rel homology domain (RHD) | |||||||
|---|---|---|---|---|---|---|---|
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| Identifiers | |||||||
| Symbol | RHD | ||||||
| Pfam | PF00554 | ||||||
| InterPro | IPR011539 | ||||||
| PROSITE | PDOC00924 | ||||||
| SCOP2 | 1svc /SCOPe /SUPFAM | ||||||
| CDD | cd07827 | ||||||
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TheRel homology domain (RHD) is aprotein domain found in a family of eukaryotictranscription factors,[2] including bothNF-κB andNFAT, among others. Some of these transcription factors appear to form multi-proteinDNA-bound complexes.[3]Phosphorylation of the RHD appears to play a role in the regulation of some of these transcription factors, acting to modulate the expression of their target genes.[4]
The RHD is composed of twoimmunoglobulin-likebeta barrel subdomains that grip the DNA in the major groove. TheN-terminal specificity domain resembles the core domain of thep53 transcription factor, and contains a recognition loop that interacts with DNA bases. In the case ofNF-κB, theC-terminal dimerization subdomain determines dimerization propensity with other proteins in theNF-κB/Rel protein family. The dimerization subdomain is immediately followed by anuclear localization sequence that also comprises the site for inhibitory interactions withIκB.[1]
