Ribosomal protein S4, Y-linked 2 also known asRPS4Y2 is aprotein which in humans is encoded by theRPS4Y2 gene which resides on theY chromosome.^[1][2]

Cytoplasmicribosomes, organelles that catalyzeprotein synthesis, consist of a small40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene,RPS4Y1 and the ribosomal protein S4, X-linked (RPS4X). The 3 isoforms encoded by these genes are not identical, but appear to be functionally equivalent.^[3] Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. It has been suggested thathaploinsufficiency of the ribosomal protein S4 genes plays a role inTurner syndrome; however, this hypothesis is controversial.^[4]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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