Chemical compound
Pharmaceutical compound
Proligestone Clinical data Trade names Covinan, Delvosteron Other names 14α,17α-Propylidenedioxyprogesterone; 14α,17α-Dihydroxyprogesterone cyclic acetal with propionaldehyde; 14α,17α-Dihydroxypregn-4-ene-3,20-dione cyclic acetal with propionaldehyde Drug class Progestogen ;Progestin ATC code Identifiers CAS Number PubChem CID ChemSpider UNII KEGG ChEMBL CompTox Dashboard (EPA) ECHA InfoCard 100.041.733 Chemical and physical data Formula C 24 H 34 O 4 Molar mass −1 3D model (JSmol ) InChI=1S/C24H34O4/c1-5-20-27-23(15(2)25)12-13-24(28-20)19-7-6-16-14-17(26)8-10-21(16,3)18(19)9-11-22(23,24)4/h14,18-20H,5-13H2,1-4H3/t18-,19+,20?,21-,22+,23-,24+/m0/s1
Key:MQSDUYIXZDSLSZ-QSDCUGRSSA-N
Proligestone , sold under the brand namesCovinan andDelvosteron , is aprogestin medication which is used inveterinary medicine .[ 1] [ 2] [ 3]
Proligestone is used to controlestrus in dogs and cats and has also been used to treathypersexuality in dogs and cats.[ 4]
Proligestone is aprogestogen , or anagonist of theprogesterone receptor (PR).
Proligestone, also known as 14α,17α-propylidenedioxyprogesterone or as 14α,17α-dihydroxyprogesterone cyclic acetal with propionaldehyde, as well as 14α,17α-propylidenedioxypregn-4-ene-3,20-dione, is asynthetic pregnane steroid and aderivative ofprogesterone and17α-hydroxyprogesterone .[ 1] [ 2] cyclic ketal of 14α,17α-dihydroxyprogesterone.[ 5] [ 6] [ 7]
Proligestone was described as early as 1968 and was introduced for veterinary use in 1975.[ 1] [ 8] [ 9]
Society and culture [ edit ] Proligestone is thegeneric name of the drug and itsINN Tooltip International Nonproprietary Name andBAN Tooltip British Approved Name .[ 1] [ 2] [ 3]
Proligestone is marketed under the brand names Covinan and Delvosteron.[ 1] [ 2] [ 3]
Proligestone is or has been available for veterinary use inArgentina ,Australia ,Austria ,Belgium ,Czechoslovakia ,France ,Germany ,Ireland ,Italy , theNetherlands ,New Zealand ,Poland ,South Africa ,Switzerland , and theUnited Kingdom .[ 2] [ 3]
PR Tooltip Progesterone receptor
Agonists Testosterone derivatives: Progestins:6,6-Difluoronorethisterone 6,6-Difluoronorethisterone acetate 17α-Allyl-19-nortestosterone Allylestrenol Altrenogest Chloroethynylnorgestrel Cingestol Danazol Desogestrel Dienogest Ethinylandrostenediol Ethisterone Ethynerone Etonogestrel Etynodiol Etynodiol diacetate Gestodene Gestrinone Levonorgestrel Levonorgestrel esters (e.g.,levonorgestrel butanoate )Lynestrenol Lynestrenol phenylpropionate Metynodiol Metynodiol diacetate Norelgestromin Norethisterone (norethindrone) Norethisterone esters (e.g.,norethisterone acetate ,norethisterone enanthate )Noretynodrel Norgesterone Norgestimate Norgestrel Norgestrienone Norvinisterone Oxendolone Quingestanol Quingestanol acetate Tibolone Tigestol Tosagestin ; Anabolic–androgenic steroids:11β-Methyl-19-nortestosterone 11β-Methyl-19-nortestosterone dodecylcarbonate 19-Nor-5-androstenediol 19-Nor-5-androstenedione 19-Nordehydroepiandrosterone Bolandiol Bolandiol dipropionate Bolandione Dimethisterone Dienedione Dienolone Dimethandrolone Dimethandrolone buciclate Dimethandrolone dodecylcarbonate Dimethandrolone undecanoate Dimethyldienolone Dimethyltrienolone Ethyldienolone Ethylestrenol (ethylnandrol) Methyldienolone Metribolone (R-1881) Methoxydienone (methoxygonadiene) Mibolerone Nandrolone Nandrolone esters (e.g.,nandrolone decanoate ,nandrolone phenylpropionate )Norethandrolone Normethandrone (methylestrenolone, normethandrolone, normethisterone) RU-2309 Tetrahydrogestrinone Trenbolone (trienolone) Trenbolone esters (e.g.,trenbolone acetate ,trenbolone enanthate )Trendione Trestolone Trestolone acetate MixedSPRMs Tooltip Selective progesterone receptor modulators ) Antagonists
mPR Tooltip Membrane progesterone receptor PAQR Tooltip Progestin and adipoQ receptor )
