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Pritumumab

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From Wikipedia, the free encyclopedia

Monoclonal antibody

Pharmaceutical compound

Pritumumab
Monoclonal antibody
Type	Whole antibody
Source	Human
Target	vimentin
Clinical data
ATC code	none
Identifiers
CAS Number	499212-74-7^N
ChemSpider	none
UNII	Z6Q90D1G53
Chemical and physical data
Formula	C₆₄₄₀H₉₉₆₈N₁₇₀₈O₂₀₁₆S₄₂
Molar mass	144923.04 g·mol⁻¹
^NY (what is this?) (verify)

Pritumumab (PTB) is ahuman monoclonal antibody targeted againstglioma.^[1] It works by binding to the ecto-domain ofvimentin on the surface of cancer cells.^[1]^[2] developed byNascent Biotech.

It is in clinical trials for the treatment ofglioma.^[3]^[4] TheFDA grantedorphan drug designation in 2015.

The target ofPritumumab, cell surface vimentin, has been implicated in the replication of coronavirus, specifically in Severe acute respiratory syndrome coronavirus (SARS-CoV).^[5]

PTB has been proposed as a potential treatment for COVID-19 and related Viral Infections.^[6]

References

[edit]

^^a ^bBabic I, Nurmemmedov E, Yenugonda VM, Juarez T, Nomura N, Pingle SC, Glassy MC, Kesari S (February 2018). "Pritumumab, the first therapeutic antibody for glioma patients".Human Antibodies.26 (2):95–101.doi:10.3233/HAB-170326.PMID 29036806.S2CID 3266191.
^"International Nonproprietary Names for Pharmaceutical Substances (INN)"(PDF).WHO Drug Information.18 (1). 2004. Archived fromthe original(PDF) on 11 February 2012.
^"Nascent Biologics Proven Cancer Cure Back in the Hands Of U.S. Inventor After 27 Years In Japan". Nascent Biologics. 1 October 2009. Archived fromthe original on 2011-07-14.
^Clinical trial numberNCT04396717 for "Safety Study of Pritumumab in Brain Cancer" atClinicalTrials.gov
^Yu YT, Chien SC, Chen IY, Lai CT, Tsay YG, Chang SC, Chang MF (January 2016)."Surface vimentin is critical for the cell entry of SARS-CoV".Journal of Biomedical Science.23: 14.doi:10.1186/s12929-016-0234-7.PMC 4724099.PMID 26801988.
^"Race For Vaccine Intensifies As COVID-19 Second Wave of Outbreaks Threatens".Financialnewsmedia.com. 17 June 2020.

Monoclonal antibodies for tumors

Tumor

Human	Adecatumumab^§ Amivantamab (+hyaluronidase) Ascrinvacumab^§ Balstilimab^† Botensilimab Cixutumumab^§ Conatumumab^§ Cosibelimab Daratumumab Drozitumab^§ Duligotumab^§ Dusigitumab^§ Enfortumab vedotin Enoticumab^§ Figitumumab^§ Flanvotumab^§ Ganitumab^† Glembatumumab vedotin^† Intetumumab^§ Ipilimumab Iratumumab^§ Istiratumab Icrucumab^§ Lexatumumab^§ Linvoseltamab Lucatumumab^§ Mapatumumab^§ Narnatumab^§ Necitumumab Nesvacumab^§ Nivolumab^# (+hyaluronidase,+relatlimab) Ofatumumab Olaratumab^† Panitumumab Patritumab^§ Pritumumab^§ Radretumab^§ Ramucirumab Rilotumumab^† Robatumumab^§ Seribantumab^§ Sugemalimab Tarextumab^§ Tisotumab vedotin Teprotumumab^† Tovetumab^§ Vantictumab^§ Votumumab^§ Zalutumumab^†
Mouse	Abagovomab Altumomab pentetate Anatumomab mafenatox Arcitumomab Bectumomab Blinatumomab Capromab pendetide Detumomab Edrecolomab Ibritumomab tiuxetan Igovomab Lilotomab Minretumomab Mitumomab Nacolomab tafenatox Moxetumomab pasudotox Naptumomab estafenatox Oregovomab Pemtumomab^† Racotumomab Satumomab pendetide Solitomab Taplitumomab paptox Nofetumomab merpentan Pintumomab Tenatumomab Tositumomab
Chimeric	Amatuximab^§ Bavituximab^§ Brentuximab vedotin Carotuximab^† Cetuximab Derlotuximab biotin^§ Dinutuximab Ecromeximab^§ Ensituximab^§ Futuximab^§ Girentuximab^† Indatuximab ravtansine^§ Isatuximab Loncastuximab tesirine Margetuximab Mirvetuximab soravtansine Rituximab^# Siltuximab Ublituximab Zolbetuximab
Humanized	Abituzumab^§ Alemtuzumab Atezolizumab (+hyaluronidase) Axatilimab Belantamab mafodotin Bevacizumab Bivatuzumab mertansine^§ Brontictuzumab^§ Cantuzumab mertansine^§ Cantuzumab ravtansine^§ Cirmtuzumab Citatuzumab bogatox^§ Clivatuzumab tetraxetan Cofetuzumab pelidotin Dacetuzumab^§ Demcizumab^§ Dalotuzumab^§ Datopotamab deruxtecan Denintuzumab mafodotin^§ Elotuzumab Emactuzumab Emibetuzumab^§ Enoblituzumab^§ Epcoritamab Etaracizumab^§ Farletuzumab^§ Ficlatuzumab^§ Flotetuzumab^§ Gemtuzumab ozogamicin Glofitamab Imgatuzumab^§ Inotuzumab ozogamicin Labetuzumab^§ Lifastuzumab vedotin^§ Lintuzumab^§ Lorvotuzumab mertansine^§ Lumretuzumab^§ Matuzumab^§ Milatuzumab^§ Naxitamab Nimotuzumab^† Obinutuzumab Ocaratuzumab^§ Odronextamab Otlertuzumab^§ Onartuzumab^§ Oportuzumab monatox^† Parsatuzumab^§ Pembrolizumab^# (+berahyaluronidase alfa) Penpulimab Pertuzumab Pinatuzumab vedotin^§ Polatuzumab vedotin Rosmantuzumab Rovalpituzumab tesirine^† Sacituzumab govitecan Sibrotuzumab^§ Simtuzumab^§ Sofituzumab vedotin^§ Tacatuzumab tetraxetan^§ Tigatuzumab^§ Trastuzumab^# (+deruxtecan /+emtansine) Tucotuzumab celmoleukin^§ Vandortuzumab vedotin^§ Vanucizumab^§ Veltuzumab^§ Vorsetuzumab mafodotin^§ Zenocutuzumab
Rat/mouse hybrid	Catumaxomab Ertumaxomab^§
Chimeric + humanized	Depatuxizumab mafodotin^† Duvortuxizumab Ontuxizumab^§

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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