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| ECHA InfoCard | 100.001.480 |
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| Formula | C17H13N3O5S2 |
| Molar mass | 403.43 g·mol−1 |
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Phthalylsulfathiazole (also known assulfathalidine)[1] is a sulfonamidebroad-spectrum antimicrobial used primarily for treating gastrointestinal infections.[2][3]
Phthalylsulfathiazole is indicated for treating various intestinal conditions, includingdysentery,colitis,gastroenteritis, and for preoperative preparation in intestinal surgery.[2][4] It may be administered in combination with other antimicrobials such asmetronidazole,furazolidone, orneomycin for enhanced efficacy.[3]
Like all antibiotics, phthalylsulfathiazole should be carefully monitored to avoid promotingbacterial resistance.[3]
Phthalylsulfathiazole is typically given orally in tablet form to target intestinal infections directly.[2] Due to thephthalic acid substitution on the aniline nitrogen, it remains unabsorbed in the bloodstream, focusing its action within the gut.[5]
Common side effects include nausea, stomach upset, and skin rash.[6] Rare but serious adverse effects may involvevitamin B deficiency,agranulocytosis, oraplastic anemia.[7]
Phthalylsulfathiazole acts by competitive antagonism withpara-aminobenzoic acid, inhibiting thedihydropteroate synthetase enzyme crucial fordihydrofolic acid synthesis. This inhibition disruptspurine andpyrimidine synthesis, impairing bacterial growth and reproduction.[8] Once in the large intestine, phthalylsulfathiazole hydrolyzes to release sulfathiazole, the active antimicrobial component.[9]
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