Phosphorolysis is thecleavage of a compound in which inorganicphosphate is the attacking group. It is analogous tohydrolysis.[1]
An example of this isglycogen breakdown by glycogen phosphorylase, which catalyzes attack by inorganic phosphate on the terminal glycosyl residue at the nonreducing end of aglycogen molecule. If the glycogen chain hasn glucose units, the products of a single phosphorolytic event are one molecule ofglucose 1-phosphate and a glycogen chain ofn-1 remaining glucose units.
In addition, sometimes phosphorolysis is preferable to hydrolysis (like in the breakdown of glycogen orstarch, as in the example above) because glucose 1-phosphate yields more ATP than does free glucose when subsequentlycatabolized topyruvate.
Another example of phosphorolysis is seen in the conversion of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate in glycolysis. The mechanism involves phosphorolysis.
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