POLE4
Identifiers
Aliases	POLE4, YHHQ1, p12, polymerase (DNA) epsilon 4, accessory subunit, DNA polymerase epsilon 4, accessory subunit
External IDs	OMIM:607269;MGI:1914229;HomoloGene:41339;GeneCards:POLE4;OMA:POLE4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p12 Start 74,958,643bp[1] End 74,970,128bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 82,595,973bp[2] End 82,682,346bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte cingulate gyrus anterior cingulate cortex mucosa of transverse colon right adrenal cortex popliteal artery tibial arteries monocyte left adrenal gland gastrocnemius muscle Top expressed in zygote secondary oocyte primary oocyte yolk sac retinal pigment epithelium ciliary body right kidney ventricular zone embryo iris More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity DNA binding DNA-directed DNA polymerase activity nucleotidyltransferase activity protein binding protein heterodimerization activity Cellular component epsilon DNA polymerase complex nucleus nucleoplasm Biological process histone H3 acetylation DNA biosynthetic process G1/S transition of mitotic cell cycle DNA replication initiation telomere maintenance via semi-conservative replication Sources:Amigo /QuickGO
Orthologs Species Human Mouse Entrez 56655 66979 Ensembl ENSG00000115350 ENSMUSG00000030042 UniProt Q9NR33 Q9CQ36 RefSeq (mRNA) NM_019896 NM_025882 NM_001370295 RefSeq (protein) NP_063949 NP_080158 NP_001357224 Location (UCSC) Chr 2: 74.96 – 74.97 Mb Chr 6: 82.6 – 82.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Polymerase (DNA-directed), epsilon 4, accessory subunit is aprotein that in humans is encoded by thePOLE4gene.^[5]

POLE4 is ahistone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.^[5]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

This article on agene on humanchromosome 2 is astub. You can help Wikipedia byadding missing information.

• v
• t
• e

• Genes on human chromosome 2
• Human chromosome 2 gene stubs

• Articles with short description
• Short description matches Wikidata
• Wikipedia articles incorporating text from the United States National Library of Medicine
• All stub articles