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Oxaceprol

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From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

Oxaceprol
Clinical data

Other names	(2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid
AHFS/Drugs.com	International Drug Names
ATC code	D11AX09 (WHO) M01AX24 (WHO)
Identifiers
IUPAC name (4R)-1-acetyl-4-hydroxy-L-proline
CAS Number	33996-33-7^Y
PubChemCID	65784
ChemSpider	59203
UNII	Q0XV76B96L
KEGG	D07215^Y
ChEBI	CHEBI:233149
ChEMBL	ChEMBL1407356
CompTox Dashboard(EPA)	DTXSID2046410
ECHA InfoCard	100.047.058
Chemical and physical data
Formula	C₇H₁₁NO₄
Molar mass	173.168 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(=O)N1C[C@@H](C[C@H]1C(=O)O)O
InChI InChI=1S/C7H11NO4/c1-4(9)8-3-5(10)2-6(8)7(11)12/h5-6,10H,2-3H2,1H3,(H,11,12)/t5-,6+/m1/s1 Key:BAPRUDZDYCKSOQ-RITPCOANSA-N
(verify)

Oxaceprol is an anti-inflammatory drug used in the treatment ofosteoarthritis.^[1] It is derived fromL-proline, a DNA-encodedamino acid. The active effect of Oxaceprol is to inhibit the adhesion and migration ofwhite blood cells.^[2]

References

[edit]

^Herrmann G, Steeger D, Klasser M, Wirbitzky J, Fürst M, Venbrocks R, et al. (2000). "Oxaceprol is a well-tolerated therapy for osteoarthritis with efficacy equivalent to diclofenac".Clinical Rheumatology.19 (2):99–104.doi:10.1007/s100670050025.PMID 10791619.S2CID 25654850.
^Clayton JJ (August 2007)."Nutraceuticals in the management of osteoarthritis".Orthopedics.30 (8):624–9, quiz 630-1.doi:10.3928/01477447-20070801-13.PMID 17727018. Retrieved2013-06-08.

External links

[edit]

"Oxaceprol".Drug Information Portal. U.S. National Library of Medicine. Archived fromthe original on November 4, 2022.

v t e Otherdermatological preparations (D11)
Anti-seborrheics	Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide) Ciclopirox olamine (ciclopirox) Climbazole Clotrimazole Ketoconazole Miconazole Piroctone olamine Selenium disulfide (selenium sulfide) Xenysalate Zinc pyrithione (pyrithione zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea (urea-containing cream) Lithium salts Lithium gluconate Lithium succinate Topical corticosteroids (e.g.,hydrocortisone)
Skin lightening	Hydroquinone Mequinol Monobenzone
Skin darkening	Afamelanotide Melanotan II
Anti-inflammatories	Alitretinoin Gamolenic acid Oxaceprol Pimecrolimus Tacrolimus Topical corticosteroids (e.g.,hydrocortisone)
Alopecia treatments	5α-Reductase inhibitors Alfatradiol Dutasteride Finasteride Saw palmetto extract Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Topilutamide (fluridil) Potassium channel openers Minoxidil Others Minoxidil/finasteride Nepidermin PP405 Ritlecitinib
Hair growth inhibitors	5α-Reductase inhibitors Dutasteride Finasteride Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Eflornithine
Others	Abrocitinib Aminobenzoate potassium Androgens (e.g.,testosterone) Atinvicitinib Benzoylperoxide Brimonidine Caffeine Calcium gluconate Collagen Crisaborole Cromoglicic acid Delgocitinib Deoxycholic acid Diclofenac Dupilumab Estrogens (e.g.,estradiol) Glycopyrronium bromide Glycopyrronium tosylate Hyaluronic acid Hydrogen peroxide Ilunocitinib Ivermectin Lebrikizumab Lokivetmab Magnesium sulfate Metandienone Nemolizumab Oclacitinib Oxymetazoline Povidone-iodine Pregnenolone acetate Progestogens (e.g.,progesterone) Ruxolitinib Sofpironium bromide Tiratricol Tralokinumab

v t e Nonsteroidal anti-inflammatory drugs (NSAIDs) (primarilyM01A andM02A, alsoN02BA)
pyrazolones / pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡
salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bufexamac Bumadizone Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Mofezolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†
oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Pivoxicam Tenoxicam
propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pelubiprofen Piketoprofen Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ Zaltoprofen COX-inhibiting nitric oxide donator:Naproxcinod
n-arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Floctafenine Flufenamic acid Flunixin Flutiazin Glafenine^† Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid
COX-2 inhibitors (coxibs)	Apricoxib Celecoxib (+tramadol) Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†
other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Grapiprant^‡ Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase / orgotein Tenidap
NSAID combinations	Ibuprofen/famotidine Ibuprofen/hydrocodone Ibuprofen/oxycodone Ibuprofen/paracetamol Meloxicam/bupivacaine Meloxicam/rizatriptan Naproxen/diphenhydramine Naproxen/esomeprazole
Key:underline indicates initially developed first-in-class compound of specific group;^#WHO-Essential Medicines;^†withdrawn drugs;^‡veterinary use.
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