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Mersalyl

From Wikipedia, the free encyclopedia
Organomercury compound once used diuretic
Mersalyl
Names
IUPAC name
(3-{[2-(Carboxymethoxy)benzoyl]amino}-2-methoxypropyl)(hydroxy)mercury
Other names
Mersalyl acid, salyrganic acid
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard100.006.943Edit this at Wikidata
UNII
  • InChI=1S/C13H16NO5.Hg.H2O/c1-9(18-2)7-14-13(17)10-5-3-4-6-11(10)19-8-12(15)16;;/h3-6,9H,1,7-8H2,2H3,(H,14,17)(H,15,16);;1H2/q;+1;/p-1 checkY
    Key: HQRSUIDICNOLPX-UHFFFAOYSA-M checkY
  • InChI=1/C13H16NO5.Hg.H2O/c1-9(18-2)7-14-13(17)10-5-3-4-6-11(10)19-8-12(15)16;;/h3-6,9H,1,7-8H2,2H3,(H,14,17)(H,15,16);;1H2/q;+1;/p-1/rC13H17HgNO6/c1-20-9(6-14-19)7-15-13(18)10-4-2-3-5-11(10)21-8-12(16)17/h2-5,9,19H,6-8H2,1H3,(H,15,18)(H,16,17)
    Key: HQRSUIDICNOLPX-SCJHNVIKAK
  • O[Hg]CC(OC)CNC(=O)c1ccccc1OCC(O)=O
Properties
C13H18HgNO6
Molar mass484.87512 g/mol
Pharmacology
C03BC01 (WHO)
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Chemical compound

Mersalyl (Mersal) is anorganomercury compound[1] andmercurial diuretic. It is only rarely used as a drug, having been superseded bythiazides andloop diuretics that are less toxic because they do not containmercury. It features a Hg(II) centre. Mersalyl was originally adapted fromcalomel (Hg2Cl2), a diuretic discovered byParacelsus.

See also

[edit]
  • Thiomersal – Organomercury antiseptic and antifungal agent
  • Nitromersol – Organomercury antiseptic and antifungal agent

References

[edit]
  1. ^Stewart, J. H.; Edwards, K. D. (1965)."Clinical comparison of frusemide with bendrofluazide, mersalyl, and ethacrynic acid".British Medical Journal.2 (5473):1277–1281.doi:10.1136/bmj.2.5473.1277.PMC 1846704.PMID 5849145.
Mercury(I)
Mercury(II)
Organomercury
compounds
Mercury(IV)
Amalgams
Mercury cations
Sulfonamides
(andetacrynic acid)
CA inhibitors (atPT)
Loop (Na-K-Cl atAL)
Thiazides (Na-Cl atDCT,
Calcium-sparing)
Thiazide-likes (primarilyDCT)
Potassium-sparing (atCD)
ESC blockers
Aldosterone antagonists
Osmotic diuretics (PT,DL)
Vasopressin receptor inhibitors
(DCT andCD)
Other
Combination products
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