Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family oftranscription factors. The protein contains three domains, anN-terminalDNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptionalrepression. It may play a role in cell cycle regulation. Like the viral version, this gene is anoncogene, and rearrangements of the gene (often involving deletion in the C-terminal domain) causes cancer.[8]
MYB factors represent a family of proteins that include the conserved MYB DNA-binding domain. Plants contain a MYB-protein subfamily that is characterised by the R2R3-type MYB domain.[9]
In maize,phlobaphenes are synthesized in the flavonoids synthetic pathway[10] from polymerisation offlavan-4-ols[11][12] which encodes an R2R3 myb-liketranscriptional activator[13] of the A1 gene encoding for thedihydroflavonol 4-reductase (reducingdihydroflavonols into flavan-4-ols)[14] while another gene (Suppressor of Pericarp Pigmentation 1 or SPP1) acts as asuppressor.[15] The maize P gene encodes a Myb homolog that recognizes the sequence CCWACC, in sharp contrast with the YAACGG bound by vertebrate Myb proteins.[16]
Ruby is a MYB transcriptional activator of genes that produceanthocyanin in citrus fruits. In most citrus varieties Ruby is non-functional, but in blood oranges it upregulates anthocyanin production to produce the characteristic red color of the fruit.[19]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Chen Y, Xu H, Liu J, Zhang C, Leutz A, Mo X (Jul 2007). "The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells".Biochem Biophys Res Commun.360 (2):433–6.Bibcode:2007BBRC..360..433C.doi:10.1016/j.bbrc.2007.06.078.PMID17599807.
^Klempnauer KH, Symonds G, Evan GI, Bishop JM (June 1984). "Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by chicken c-myb gene".Cell.37 (2):537–47.doi:10.1016/0092-8674(84)90384-2.PMID6327074.S2CID46196167.
^Lee EA, Harper V (2002). "Suppressor of Pericarp Pigmentation 1 (SPP1), a novel gene involved in phlobaphene accumulation in maize (Zea mays L.) pericarps".Maydica.47 (1):51–58.INIST13772300
^Grotewold E, Drummond BJ, Bowen B, Peterson T (1994). "The myb-homologous P gene controls phlobaphene pigmentation in maize floral organs by directly activating a flavonoid biosynthetic gene subset".Cell.76 (3):543–554.doi:10.1016/0092-8674(94)90117-1.PMID8313474.S2CID42197232.
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Janssen JW, Vernole P, de Boer PA, Oosterhuis JW, Collard JG (1986). "Sublocalization of c-myb to 6q21----q23 by in situ hybridization and c-myb expression in a human teratocarcinoma with 6q rearrangements".Cytogenet. Cell Genet.41 (3):129–35.doi:10.1159/000132217.PMID3007038.
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Jacobs SM, Gorse KM, Westin EH (1994). "Identification of a second promoter in the human c-myb proto-oncogene".Oncogene.9 (1):227–35.PMID8302584.
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