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MRS-1706

From Wikipedia, the free encyclopedia
MRS-1706
Names
IUPAC name
N-(4-Acetylphenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide
Other names
MRS 1706
Identifiers
3D model (JSmol)
ChemSpider
MeSHC496145
UNII
  • InChI=1S/C27H29N5O5/c1-4-14-31-25-23(26(35)32(15-5-2)27(31)36)29-24(30-25)19-8-12-21(13-9-19)37-16-22(34)28-20-10-6-18(7-11-20)17(3)33/h6-13H,4-5,14-16H2,1-3H3,(H,28,34)(H,29,30) ☒N
    Key: ZKUCFFYOQOJLGT-UHFFFAOYSA-N ☒N
  • InChI=1/C27H29N5O5/c1-4-14-31-25-23(26(35)32(15-5-2)27(31)36)29-24(30-25)19-8-12-21(13-9-19)37-16-22(34)28-20-10-6-18(7-11-20)17(3)33/h6-13H,4-5,14-16H2,1-3H3,(H,28,34)(H,29,30)
    Key: ZKUCFFYOQOJLGT-UHFFFAOYAX
  • CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3=CC=C(C=C3)OCC(=O)NC4=CC=C(C=C4)C(=O)C
Properties
C27H29N5O5
Molar mass503.56
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Chemical compound

MRS-1706 is a selectiveinverse agonist for theadenosineA2Breceptor.[1] It inhibits release ofinterleukins and has an antiinflammatory effect.[2][3]

References

[edit]
  1. ^Li Q, Ye K, Blad CC, den Dulk H, Brouwer J, Ijzerman AP, Beukers MW (February 2007). "ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor".The Journal of Pharmacology and Experimental Therapeutics.320 (2):637–45.doi:10.1124/jpet.106.111203.PMID 17077318.
  2. ^Vazquez JF, Clement HW, Sommer O, Schulz E, van Calker D (May 2008)."Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study".Journal of Neurochemistry.105 (3):904–9.doi:10.1111/j.1471-4159.2007.05191.x.PMID 18088370.
  3. ^Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Dikov MM, Blackburn MR, et al. (June 2008)."Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells".Journal of Immunology.180 (11):7212–20.doi:10.4049/jimmunol.180.11.7212.PMC 3628765.PMID 18490720.
Receptor
(ligands)
P0 (adenine)
P1
(adenosine)
P2
(nucleotide)
P2X
(ATPTooltip Adenosine triphosphate)
P2Y
Transporter
(blockers)
CNTsTooltip Concentrative nucleoside transporters
ENTsTooltip Equilibrative nucleoside transporters
PMATTooltip Plasma membrane monoamine transporter
Enzyme
(inhibitors)
XOTooltip Xanthine oxidase
Others
Others


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