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The highway starts at the crossing of theMoscow Ring Road and Volgogradsky Prospekt and runs southeast throughLyubertsy, crossing theOka River atKolomna. The Ural Highway continues across nine regions ofRussia, passing through a dangerous mountain stretch before terminating at Chelyabinsk. The road continues from Chelyabinsk further east toOmsk,Novosibirsk,Irkutsk as the Russianroute R254.
Routes marked with § are having sections in theRussian-occupied regions of Eastern and Southern Ukraine (Crimea, Donetsk, Luhansk, etc.). Routes marked with a strikethrough have been eitherdecommissioned or have been canceled.