| Class 1Class 1 U.S. senators belong to the electoral cycle that has recently been contested in2006,2012,2018, and2024. The next election will be in 2030. | C | Class 3Class 3 U.S. senators belong to the electoral cycle that has recently been contested in2004,2010,2016, and2022. The next election will be in2026 (special) and2028. |
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| # | Senator | Party | Dates in office | Electoral history | T | T | Electoral history | Dates in office | Party | Senator | # |
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| 1 | John Smith | Democratic- Republican | Apr 1, 1803 – Apr 25, 1808 | Elected in 1803.[1]Resigned. | 1 | 8th | 1 | Elected in 1803.[1]Retired. | Apr 1, 1803 – Mar 3, 1807 | Democratic- Republican |  Thomas Worthington | 1 |
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| 9th |
| 10th | 2 | Elected in 1807.[2]Resigned. | Mar 4, 1807 – Mar 3, 1809 | Democratic- Republican |  Edward Tiffin | 2 |
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| Vacant | Apr 25, 1808 – Dec 12, 1808 | |
| 2 |  Return J. Meigs Jr. | Democratic- Republican | Dec 12, 1808 – Dec 8, 1810 | Elected in 1808 to finish Smith's term.[3] |
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| Elected in 1808 to full term.[3]Resigned to becomeGovernor of Ohio. | 2 | 11th | | Mar 4, 1809 – May 18, 1809 | Vacant |
| Appointed to continue Tiffin's term.[3]Retired when successor elected. | May 18, 1809 – Dec 11, 1809 | Democratic- Republican | Stanley Griswold | 3 |
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| Vacant | Dec 8, 1810 – Dec 15, 1810 | |
| Elected in 1809 to finish Tiffin's term.Retired. | Dec 11, 1809 – Mar 3, 1813 | Democratic- Republican |  Alexander Campbell | 4 |
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| 3 |  Thomas Worthington | Democratic- Republican | Dec 15, 1810 – Dec 1, 1814 | Elected in 1810 to finish Meigs's term.Resigned to becomeGovernor of Ohio. |
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| 12th |
| 13th | 3 | Elected in 1813.Retired. | Mar 4, 1813 – Mar 3, 1819 | Democratic- Republican |  Jeremiah Morrow | 5 |
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| Vacant | Dec 1, 1814 – Dec 10, 1814 | |
| 4 | Joseph Kerr | Democratic- Republican | Dec 10, 1814 – Mar 3, 1815 | Elected in 1814 to finish Meigs's term.Retired. |
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| 5 |  Benjamin Ruggles | Democratic- Republican | Mar 4, 1815 – Mar 3, 1833 | Elected in 1815. | 3 | 14th |
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| 15th |
| 16th | 4 | Elected in 1819.Died. | Mar 4, 1819 – Dec 13, 1821 | Democratic- Republican |  William A. Trimble | 6 |
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| Re-elected in 1821. | 4 | 17th |
| | Dec 13, 1821 – Jan 3, 1822 | Vacant |
| Elected in 1822 to finish Trimble's term.Lost re-election. | Jan 3, 1822 – Mar 3, 1825 | Democratic- Republican |  Ethan Allen Brown | 7 |
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| 18th |
National Republican | 19th | 5 | Elected in 1824.Resigned to becomeU.S. Minister to Colombia. | Mar 4, 1825 – May 20, 1828 | National Republican |  William Henry Harrison | 8 |
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| Re-elected in 1827.Retired. | 5 | 20th |
| | May 20, 1828 – Dec 10, 1828 | Vacant |
| Elected in 1828 to finish Harrison's term.Retired. | Dec 10, 1828 – Mar 3, 1831 | National Republican |  Jacob Burnet | 9 |
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| 21st |
| 22nd | 6 | Elected in 1830.Lost re-election. | Mar 4, 1831 – Mar 3, 1837 | National Republican |  Thomas Ewing | 10 |
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| 6 |  Thomas Morris | Jacksonian | Mar 4, 1833 – Mar 3, 1839 | Elected in 1833.Lost re-election. | 6 | 23rd |
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| 24th |
| Democratic | 25th | 7 | Elected in 1837. | Mar 4, 1837 – Mar 3, 1849 | Democratic |  William Allen | 11 |
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| 7 |  Benjamin Tappan | Democratic | Mar 4, 1839 – Mar 3, 1845 | Elected in 1838.Retired. | 7 | 26th |
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| 27th |
| 28th | 8 | Re-elected in 1842.Lost re-election. |
| 8 |  Thomas Corwin | Whig | Mar 4, 1845 – Jul 20, 1850 | Elected in 1844.[4]Resigned to becomeU.S. Secretary of the Treasury. | 8 | 29th |
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| 30th |
| 31st | 9 | Elected in 1849.Retired. | Mar 4, 1849 – Mar 3, 1855 | Free Soil |  Salmon P. Chase | 12 |
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| 9 |  Thomas Ewing | Whig | Jul 20, 1850 – Mar 3, 1851 | Appointed to finish Corwin's term.Lost election to the next term. |
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| Vacant | Mar 4, 1851 – Mar 15, 1851 | | 9 | 32nd |
| 10 |  Benjamin Wade | Whig | Mar 15, 1851 – Mar 3, 1869 | Elected late in 1851.[5] |
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| 33rd |
| Republican | 34th | 10 | Elected in 1854[6]Lost re-election. | Mar 4, 1855 – Mar 3, 1861 | Democratic |  George E. Pugh | 13 |
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| Re-elected in 1856. | 10 | 35th |
| 36th |
| 37th | 11 | Elected in 1860.Resigned to becomeU.S. Secretary of the Treasury. | Mar 4, 1861 – Mar 6, 1861 | Republican |  Salmon P. Chase | 14 |
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| | Mar 6, 1861 – Mar 21, 1861 | Vacant |
| Elected in 1861 to finish Chase's term. | Mar 21, 1861 – Mar 8, 1877 | Republican |  John Sherman | 15 |
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| Re-elected in 1863.Lost renomination. | 11 | 38th |
| 39th |
| 40th | 12 | Re-elected in 1866. |
| 11 |  Allen G. Thurman | Democratic | Mar 4, 1869 – Mar 3, 1881 | Elected in 1868. | 12 | 41st |
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| 42nd |
| 43rd | 13 | Re-elected in 1872.Resigned to becomeU.S. Secretary of the Treasury. |
| Re-elected in 1874.Lost re-election. | 13 | 44th |
| 45th |
| | Mar 8, 1877 – Mar 21, 1877 | Vacant |
| Elected in 1877 to finish Sherman's term.Retired. | Mar 21, 1877 – Mar 3, 1879 | Republican |  Stanley Matthews | 16 |
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| 46th | 14 | Election date unknown.Lost renomination. | Mar 4, 1879 – Mar 3, 1885 | Democratic |  George H. Pendleton | 17 |
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| 12 |  John Sherman | Republican | Mar 4, 1881 – Mar 4, 1897 | Elected in 1881. | 14 | 47th |
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| 48th |
| 49th | 15 | Elected in 1884.[7][8]Retired. | Mar 4, 1885 – Mar 3, 1891 | Democratic |  Henry B. Payne | 18 |
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| Re-elected in 1886. | 15 | 50th |
| 51st |
| 52nd | 16 | Elected in 1890.Lost re-election.[9] | Mar 4, 1891 – Mar 3, 1897 | Democratic |  Calvin S. Brice | 19 |
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| Re-elected in 1892.Resigned to becomeU.S. Secretary of State. | 16 | 53rd |
| 54th |
| 55th | 17 | Elected in 1896. | Mar 4, 1897 – Mar 3, 1909 | Republican |  Joseph B. Foraker | 20 |
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| 13 |  Mark Hanna | Republican | Mar 5, 1897 – Feb 15, 1904 | Appointed to continue Sherman's term.Elected in 1898 to finish Sherman's term.[10] |
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| Elected in 1898 to the next term.Died. | 17 | 56th |
| 57th |
| 58th | 18 | Re-elected in 1902.[11]Retired.[12] |
| Vacant | Feb 15, 1904 – Mar 23, 1904 | |
| 14 |  Charles W. F. Dick | Republican | Mar 23, 1904 – Mar 3, 1911 | Elected in 1904 to finish Hanna's term. |
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| Elected in 1904 to the next term.Lost re-election. | 18 | 59th |
| 60th |
| 61st | 19 | Elected Jan 12, 1909.[12]Retired. | Mar 4, 1909 – Mar 3, 1915 | Republican |  Theodore E. Burton | 21 |
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| 15 |  Atlee Pomerene | Democratic | Mar 4, 1911 – Mar 3, 1923 | Elected Jan 10, 1911. | 19 | 62nd |
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| 63rd |
| 64th | 20 | Elected in 1914.Retired torun for U.S. President.Resigned to becomeU.S. President. | Mar 4, 1915 – Jan 13, 1921 | Republican |  Warren G. Harding | 22 |
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| Re-elected in 1916.Lost re-election. | 20 | 65th |
| 66th |
| Appointed to finish Harding's term, having been elected to the next term. | Jan 14, 1921 – Mar 30, 1928 | Republican |  Frank B. Willis | 23 |
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| 67th | 21 | Elected in 1920. |
| 16 |  Simeon D. Fess | Republican | Mar 4, 1923 – Jan 3, 1935 | Elected in 1922. | 21 | 68th |
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| 69th |
| 70th | 22 | Re-elected in 1926.Died. |
| | Mar 30, 1928 – Apr 5, 1928 | Vacant |
| Appointed to continue Willis's term.Lost nomination to finish Willis's term. | Apr 5, 1928 – Dec 14, 1928 | Democratic |  Cyrus Locher | 24 |
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| Elected in 1928 to finish Willis's term.Died. | Dec 15, 1928 – Oct 28, 1929 | Republican |  Theodore E. Burton | 25 |
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| Re-elected in 1928.Lost re-election. | 22 | 71st |
| | Oct 28, 1929 – Nov 5, 1929 | Vacant |
| Appointed to continue Willis's term.Lost election to finish Willis's term. | Nov 5, 1929 – Nov 30, 1930 | Republican |  Roscoe C. McCulloch | 26 |
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| Elected in 1930 to finish Willis's term. | Dec 1, 1930 – Jan 3, 1939 | Democratic |  Robert J. Bulkley | 27 |
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| 72nd |
| 73rd | 23 | Re-elected in 1932.Lost re-election. |
| 17 |  Vic Donahey | Democratic | Jan 3, 1935 – Jan 3, 1941 | Elected in 1934.Retired. | 23 | 74th |
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| 75th |
| 76th | 24 | Elected in 1938. | Jan 3, 1939 – Jul 31, 1953 | Republican |  Robert A. Taft | 28 |
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| 18 |  Harold H. Burton | Republican | Jan 3, 1941 – Sep 30, 1945 | Elected in 1940.Resigned when appointed to theU.S. Supreme Court. | 24 | 77th |
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| 78th |
| 79th | 25 | Re-elected in 1944. |
| Vacant | Sep 30, 1945 – Oct 8, 1945 | |
| 19 |  James W. Huffman | Democratic | Oct 8, 1945 – Nov 5, 1946 | Appointed to continue Burton's term.Retired when successor elected. |
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| 20 |  Kingsley Taft | Republican | Nov 5, 1946 – Jan 3, 1947 | Elected in 1946 to finish Burton's term.Retired. |
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| 21 |  John W. Bricker | Republican | Jan 3, 1947 – Jan 3, 1959 | Elected in 1946. | 25 | 80th |
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| 81st |
| 82nd | 26 | Re-elected in 1950.Died. |
| Re-elected in 1952.Lost re-election. | 26 | 83rd |
| | Jul 31, 1953 – Nov 10, 1953 | Vacant |
| Appointed to continue Taft's term.Lost election to finish Taft's term. | Nov 10, 1953 – Dec 2, 1954 | Democratic |  Thomas Burke | 29 |
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| | Dec 2, 1954 – Dec 16, 1954 | Vacant |
| Elected in 1954 to finish Taft's term.Lost re-election. | Dec 16, 1954 – Jan 3, 1957 | Republican |  George H. Bender | 30 |
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| 84th |
| 85th | 27 | Elected in 1956. | Jan 3, 1957 – Jan 3, 1969 | Democratic |  Frank Lausche | 31 |
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| 22 |  Stephen M. Young | Democratic | Jan 3, 1959 – Jan 3, 1971 | Elected in 1958. | 27 | 86th |
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| 87th |
| 88th | 28 | Re-elected in 1962.Lost renomination. |
| Re-elected in 1964.Retired. | 28 | 89th |
| 90th |
| 91st | 29 | Elected in 1968.Resigned to becomeU.S. Attorney General. | Jan 3, 1969 – Jan 3, 1974 | Republican |  William Saxbe | 32 |
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| 23 |  Robert Taft Jr. | Republican | Jan 3, 1971 – Dec 28, 1976 | Elected in 1970.Lost re-election and resigned early. | 29 | 92nd |
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| 93rd |
| Appointed to finish Saxbe's term.Lost nomination to full term and resigned early. | Jan 4, 1974 – Dec 23, 1974 | Democratic |  Howard Metzenbaum | 33 |
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| Appointed to finish Saxbe's term, having been elected to the next term. | Dec 24, 1974 – Jan 3, 1999 | Democratic |  John Glenn | 34 |
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| 94th | 30 | Elected in 1974. |
| 24 |  Howard Metzenbaum | Democratic | Dec 29, 1976 – Jan 3, 1995 | Appointed to finish Taft's term, having been elected to the next term. |
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| Elected in 1976. | 30 | 95th |
| 96th |
| 97th | 31 | Re-elected in 1980. |
| Re-elected in 1982. | 31 | 98th |
| 99th |
| 100th | 32 | Re-elected in 1986. |
| Re-elected in 1988.Retired. | 32 | 101st |
| 102nd |
| 103rd | 33 | Re-elected in 1992.Retired. |
| 25 |  Mike DeWine | Republican | Jan 3, 1995 – Jan 3, 2007 | Elected in 1994. | 33 | 104th |
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| 105th |
| 106th | 34 | Elected in 1998. | Jan 3, 1999 – Jan 3, 2011 | Republican |  George Voinovich | 35 |
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| Re-elected in 2000.Lost re-election. | 34 | 107th |
| 108th |
| 109th | 35 | Re-elected in 2004.Retired. |
| 26 |  Sherrod Brown | Democratic | Jan 3, 2007 – Jan 3, 2025 | Elected in 2006. | 35 | 110th |
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| 111th |
| 112th | 36 | Elected in 2010. | Jan 3, 2011 – Jan 3, 2023 | Republican |  Rob Portman | 36 |
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| Re-elected in 2012. | 36 | 113th |
| 114th |
| 115th | 37 | Re-elected in 2016.Retired. |
| Re-elected in 2018.Lost re-election. | 37 | 116th |
| 117th |
| 118th | 38 | Elected in 2022.Resigned to becomeVice President of the United States. | Jan 3, 2023 – Jan 10, 2025 | Republican |  JD Vance | 37 |
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| 27 |  Bernie Moreno | Republican | Jan 3, 2025 – present | Elected in 2024. | 38 | 119th |
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| Jan 10, 2025 – Jan 18, 2025 | Vacant |
| Appointed to continue Vance's term. | Jan 18, 2025 – present | Republican |  Jon Husted | 38 |
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| To be determined in the 2026 special election. |
| 120th |
| 121st | 39 | To be determined in the 2028 election. |
| To be determined in the 2030 election. | 39 | 122nd |
| # | Senator | Party | Years in office | Electoral history | T | C | T | Electoral history | Years in office | Party | Senator | # |
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| Class 1 | Class 3 |
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