| Class 2Class 2 U.S. senators belong to the electoral cycle that has recently been contested in2002,2008,2014, and2020. The next election will be in2026. | C | Class 3Class 3 U.S. senators belong to the electoral cycle that has recently been contested in2004,2010,2016, and2022. The next election will be in2028. |
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| # | Senator | Party | Dates in office | Electoral history | T | T | Electoral history | Dates in office | Party | Senator | # |
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| Vacant | Apr 30, 1812 – Sep 3, 1812 | Louisiana did not elect its senators until four months after statehood. | 1 | 12th | 1 | Louisiana did not elect its senators until four months after statehood. | Apr 30, 1812 – Sep 3, 1812 | Vacant |
| 1 |  Jean Noël Destréhan (St. Charles Parish) | Democratic- Republican | Sep 3, 1812 – Oct 1, 1812 | Resigned | Elected in 1812. | Sep 3, 1812 – Mar 3, 1813 | Democratic- Republican | Allan B. Magruder (Opelousas) | 1 |
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| Vacant | Oct 1, 1812 – Oct 8, 1812 | |
| 2 |  Thomas Posey (Lafayette Parish) | Democratic- Republican | Oct 8, 1812 – Feb 4, 1813 | Appointed to continue Destréhan's term.Lost election to finish Destréhan's term. |
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| 3 |  James Brown (New Orleans) | Democratic- Republican | Feb 5, 1813 – Mar 3, 1817 | Elected to finish Destréhan's term.Lost election to full term. |
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| 13th | 2 | Elected in 1813 Retired. | Mar 4, 1813 – Mar 3, 1819 | Democratic- Republican | Eligius Fromentin (New Orleans) | 2 |
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| 14th |
| 4 |  William C. C. Claiborne (New Orleans) | Democratic- Republican | Mar 4, 1817 – Nov 23, 1817 | Elected in 1817.Died. | 2 | 15th |
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| Vacant | Nov 23, 1817 – Jan 12, 1818 | |
| 5 |  Henry Johnson (Donaldsonville) | Democratic- Republican | Jan 12, 1818 – May 27, 1824 | Elected to finish Claiborne's term. |
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| 16th | 3 | Elected in 1819.Resigned to becomeU.S. Minister to France. | Mar 4, 1819 – Dec 10, 1823 | Democratic- Republican |  James Brown (New Orleans) | 3 |
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| 17th |
| Elected to full term in 1823.Resigned to becomeGovernor of Louisiana. | 3 | 18th |
| | Dec 10, 1823 – Jan 15, 1824 | Vacant |
| Elected to finish Brown's term. | Jan 15, 1824 – May 19, 1833 | Democratic- Republican |  Josiah S. Johnston (Alexandria) | 4 |
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| Vacant | May 27, 1824 – Nov 19, 1824 | |
| 6 |  Dominique Bouligny (New Orleans) | Democratic- Republican | Nov 19, 1824 – Mar 3, 1829 | Elected to finish Johnson's term. |
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National Republican | 19th | 4 | Elected to full term in 1825. | National Republican |
| 20th |
| 7 |  Edward Livingston (New Orleans) | Jacksonian | Mar 4, 1829 – May 24, 1831 | Elected in 1829.[1]Resigned to becomeU.S. Secretary of State. | 4 | 21st |
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| 22nd | 5 | Re-elected in 1831.Died. |
| Vacant | May 24, 1831 – Nov 15, 1831 | |
| 8 |  George A. Waggaman (Baton Rouge) | National Republican | Nov 15, 1831 – Mar 3, 1835 | Elected to finish Livingston's term. |
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| 23rd |
| | May 19, 1833 – Dec 19, 1833 | Vacant |
| Elected to finish Johnston's term.Resigned due to ill health. | Dec 19, 1833 – Jan 5, 1837 | National Republican |  Alexander Porter (Franklin) | 5 |
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| Vacant | Mar 4, 1835 – Jan 13, 1836 | Charles Gayarré (J) waselected in 1835, but resigned due to ill health. | 5 | 24th |
| 9 |  Robert C. Nicholas (Terrebonne Parish) | Jacksonian | Jan 13, 1836 – Mar 3, 1841 | Elected to finish Gauarré's term.[data missing] |
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| | Jan 5, 1837 – Jan 12, 1837 | Vacant |
| Elected to finish Porter's term. | Jan 12, 1837 – Mar 1, 1842 | Jacksonian |  Alexandre Mouton (Vermilionville) | 6 |
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| Democratic | 25th | 6 | Re-elected in 1837.Resigned. | Democratic |
| 26th |
| 10 |  Alexander Barrow (Bayou Sara) | Whig | Mar 4, 1841 – Dec 29, 1846 | Elected in 1840.Died. | 6 | 27th |
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| | Mar 1, 1842 – Apr 14, 1842 | Vacant |
| Appointed to finish Mouton's term.Lost election to full term. | Apr 14, 1842 – Mar 3, 1843 | Whig |  Charles Conrad (New Orleans) | 7 |
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| 28th | 7 | Elected in 1843, but due to ill health did not take his seat.Died. | Mar 4, 1843 – Jan 13, 1844 | Whig |  Alexander Porter (Franklin) | 8 |
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| | Jan 13, 1844 – Feb 12, 1844 | Vacant |
| Elected to finish Porter's termLost election to full term in 1849. | Feb 12, 1844 – Mar 3, 1849 | Whig |  Henry Johnson (Donaldsonville) | 9 |
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| 29th |
| Vacant | Dec 29, 1846 – Jan 21, 1847 | |
| 11 |  Pierre Soulé (New Orleans) | Democratic | Jan 21, 1847 – Mar 3, 1847 | Elected to finish Barrow's term.[data missing] |
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| 12 |  Solomon W. Downs (New Orleans) | Democratic | Mar 4, 1847 – Mar 3, 1853 | Elected in 1847.Lost re-election. | 7 | 30th |
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| 31st | 8 | Elected in 1848.Resigned to becomeU.S. Minister to Spain. | Mar 3, 1849 – Apr 11, 1853 | Democratic |  Pierre Soulé (New Orleans) | 10 |
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| 32nd |
| 13 |  Judah P. Benjamin (New Orleans) | Whig | Mar 4, 1853 – Feb 4, 1861 | Elected in 1852. | 8 | 33rd |
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| | Apr 11, 1853 – Dec 5, 1853 | Vacant |
| Elected to finish Soulé's term. | Dec 5, 1853 – Feb 4, 1861 | Democratic |  John Slidell (New Orleans) | 11 |
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| 34th | 9 | Re-election year unknown.Resigned. |
| Democratic | 35th |
| Re-elected in 1859.Withdrew. | 9 | 36th |
| Vacant | Feb 4, 1861 – Jul 8, 1868 | Civil War andReconstruction | Civil War andReconstruction | Feb 4, 1861 – Jul 9, 1868 | Vacant |
| 37th | 10 |
| 38th |
| 10 | 39th |
| 40th | 11 |
| 14 |  John S. Harris (Natchez) | Republican | Jul 8, 1868 – Mar 3, 1871 | Elected to finish incomplete term in 1868.[data missing]. |
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| Elected to finish incomplete term.Resigned to becomeGovernor of Louisiana. | Jul 9, 1868 – Nov 1, 1872 | Republican |  William Pitt Kellogg (New Orleans) | 12 |
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| 41st |
| 15 |  J. R. West (New Orleans) | Republican | Mar 4, 1871 – Mar 3, 1877 | Election year unknown.Retired. | 11 | 42nd |
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| Senate declined to seat rival claimantsWilliam L. McMillen andP. B. S. Pinchback[2] | Nov 1, 1872 – Jan 12, 1876 | Vacant |
| 43rd | 12 |
| 44th |
| Elected to finish incomplete term in 1876.Lost re-election. | Jan 12, 1876 – Mar 3, 1879 | Democratic |  James B. Eustis (New Orleans) | 13 |
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| 16 |  William Pitt Kellogg (New Orleans) | Republican | Mar 4, 1877 – Mar 3, 1883 | Elected in 1876.Retired torun for U.S. House. | 12 | 45th |
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| 46th | 13 | Elected in 1879.Lost re-election. | Mar 4, 1879 – Mar 3, 1885 | Democratic |  Benjamin F. Jonas (New Orleans) | 14 |
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| 47th |
| 17 |  Randall L. Gibson (New Orleans) | Democratic | Mar 4, 1883 – Dec 15, 1892 | Elected in 1882. | 13 | 48th |
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| 49th | 14 | Election year unknown.Retired. | Mar 4, 1885 – Mar 3, 1891 | Democratic |  James B. Eustis (New Orleans) | 15 |
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| 50th |
| Re-elected in 1889.Died. | 14 | 51st |
| 52nd | 15 | Elected in 1891.Resigned to becomeU.S. Supreme Court Justice. | Mar 4, 1891 – Mar 12, 1894 | Democratic |  Edward Douglass White (Thibodaux) | 16 |
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| Vacant | Dec 15, 1892 – Dec 31, 1892 | |
| 18 |  Donelson Caffery (Franklin) | Democratic | Dec 31, 1892 – Mar 3, 1901 | Appointed to continue Gibson's term.Elected in 1894 to finish Gibson's term.[3] |
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| 53rd |
| Appointed to continue White's term.Elected in 1894 to finish White's term.[4]Retired. | Mar 12, 1894 – Mar 3, 1897 | Democratic |  Newton C. Blanchard (Shreveport) | 17 |
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| Elected in 1894 to the next term, before election to finish Gibson's term.Retired. | 15 | 54th |
| 55th | 16 | Elected in 1896.[5] | Mar 4, 1897 – Jun 28, 1910 | Democratic |  Samuel D. McEnery (New Orleans) | 18 |
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| 56th |
| 19 |  Murphy J. Foster (Franklin) | Democratic | Mar 4, 1901 – Mar 3, 1913 | Elected in 1900.[6] | 16 | 57th |
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| 58th | 17 | Re-elected early in 1900.[6] |
| 59th |
| Re-elected early in 1904.[7]Lost renomination. | 17 | 60th |
| 61st | 18 | Re-elected in 1908.[8]Died. |
| | Jun 28, 1910 – Dec 7, 1910 | Vacant |
| Elected to finish McEnery's term.[4]Retired. | Dec 7, 1910 – Mar 3, 1915 | Democratic |  John Thornton (Pineville) | 19 |
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| 62nd |
| 20 |  Joseph E. Ransdell (Lake Providence) | Democratic | Mar 4, 1913 – Mar 3, 1931 | Elected in 1912. | 18 | 63rd |
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| 64th | 19 | Elected early in 1912.Died. | Mar 4, 1915 – Apr 12, 1918 | Democratic |  Robert F. Broussard (New Iberia) | 20 |
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| 65th |
| | Apr 12, 1918 – Apr 22, 1918 | Vacant |
| Appointed to continue Broussard's term.Retired when elected successor qualified. | Apr 22, 1918 – Nov 5, 1918 | Democratic |  Walter Guion (New Orleans) | 21 |
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| Elected to finish Broussard's term.Retired. | Nov 6, 1918 – Mar 3, 1921 | Democratic |  Edward J. Gay (Plaquemine) | 22 |
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| Re-elected in 1918. | 19 | 66th |
| 67th | 20 | Elected in 1920. | Mar 4, 1921 – Mar 3, 1933 | Democratic |  Edwin S. Broussard (New Iberia) | 23 |
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| 68th |
| Re-elected in 1924.Lost renomination. | 20 | 69th |
| 70th | 21 | Re-elected in 1926.Lost renomination. |
| 71st |
| Vacant | Mar 4, 1931 – Jan 25, 1932 | | 21 | 72nd |
| 21 |  Huey Long (Baton Rouge) | Democratic | Jan 25, 1932 – Sep 10, 1935 | Elected in 1930, but continued to serve asLouisiana governor until Jan 25, 1932.Assassinated. |
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| 73rd | 22 | Elected in 1932. | Mar 4, 1933 – May 14, 1948 | Democratic |  John Overton (Alexandria) | 24 |
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| 74th |
| Vacant | Sep 10, 1935 – Jan 31, 1936 | |
| 22 |  Rose M. Long (Shreveport) | Democratic | Jan 31, 1936 – Jan 3, 1937 | Appointed to continue her husband's term.Elected in 1936 to finish her husband's term.[3]Retired. |
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| 23 |  Allen Ellender (Houma) | Democratic | Jan 3, 1937 – July 27, 1972 | Elected in 1936. | 22 | 75th |
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| 76th | 23 | Re-elected in 1938. |
| 77th |
| Re-elected in 1942. | 23 | 78th |
| 79th | 24 | Re-elected in 1944.Died. |
| 80th |
| | May 14, 1948 – May 18, 1948 | Vacant |
| Appointed to continue Overton's term.Retired when elected successor qualified. | May 18, 1948 – Dec 30, 1948 | Democratic |  William C. Feazel (West Monroe) | 25 |
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| Elected to finish Overton's term. | Dec 31, 1948 – Jan 3, 1987 | Democratic |  Russell Long (Baton Rouge) | 26 |
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| Re-elected in 1948. | 24 | 81st |
| 82nd | 25 | Re-elected in 1950. |
| 83rd |
| Re-elected in 1954. | 25 | 84th |
| 85th | 26 | Re-elected in 1956. |
| 86th |
| Re-elected in 1960. | 26 | 87th |
| 88th | 27 | Re-elected in 1962. |
| 89th |
| Re-elected in 1966.Died. | 27 | 90th |
| 91st | 28 | Re-elected in 1968. |
| 92nd |
| Vacant | Jul 27, 1972 – Aug 1, 1972 | |
| 24 |  Elaine Edwards (Baton Rouge) | Democratic | Aug 1, 1972 – Nov 13, 1972 | Appointed byher husband to continue Ellender's term.Retired when successor qualified and resigned early. |
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| 25 |  J. Bennett Johnston (Shreveport) | Democratic | Nov 14, 1972 – Jan 3, 1997 | Appointed to finish Ellender's term, having already been elected to the next term. |
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| Elected in 1972. | 28 | 93rd |
| 94th | 29 | Re-elected in 1974. |
| 95th |
| Re-elected in 1978. | 29 | 96th |
| 97th | 30 | Re-elected in 1980.Retired. |
| 98th |
| Re-elected in 1984. | 30 | 99th |
| 100th | 31 | Elected in 1986. | Jan 3, 1987 – Jan 3, 2005 | Democratic |  John Breaux (Crowley) | 27 |
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| 101st |
| Re-elected in 1990.Retired. | 31 | 102nd |
| 103rd | 32 | Re-elected in 1992. |
| 104th |
| 26 |  Mary Landrieu (New Orleans) | Democratic | Jan 3, 1997 – Jan 3, 2015 | Elected in 1996. | 32 | 105th |
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| 106th | 33 | Re-elected in 1998.Retired. |
| 107th |
| Re-elected in 2002 in runoff election. | 33 | 108th |
| 109th | 34 | Elected in 2004. | Jan 3, 2005 – Jan 3, 2017 | Republican |  David Vitter (Metairie) | 28 |
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| 110th |
| Re-elected in 2008.Lost re-election. | 34 | 111th |
| 112th | 35 | Re-elected in 2010.Retired.[9] |
| 113th |
| 27 |  Bill Cassidy (Baton Rouge) | Republican | Jan 3, 2015 – present | Elected in 2014 in runoff election. | 35 | 114th |
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| 115th | 36 | Elected in 2016 in runoff election. | Jan 3, 2017 – present | Republican |  John Kennedy (Madisonville) | 29 |
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| 116th |
| Re-elected in 2020. | 36 | 117th |
| 118th | 37 | Re-elected in 2022. |
| 119th |
| To be determined in the2026 election. | 37 | 120th |
| 121st | 38 | To be determined in the2028 election. |
| # | Senator | Party | Years in office | Electoral history | T | C | T | Electoral history | Years in office | Party | Senator | # |
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| Class 2 | Class 3 |
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