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Levodropropizine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Levodropropizine
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Pharmacokinetic data
Protein binding11–14%
Excretion83% via urine within 96 h
Identifiers
  • (2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
CompTox Dashboard(EPA)
ECHA InfoCard100.167.719Edit this at Wikidata
Chemical and physical data
FormulaC13H20N2O2
Molar mass236.315 g·mol−1
3D model (JSmol)
  • O[C@@H](CN2CCN(c1ccccc1)CC2)CO
  • InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1 checkY
  • Key:PTVWPYVOOKLBCG-ZDUSSCGKSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Levodropropizine is acough suppressant. It is thelevo isomer ofdropropizine. It acts as a peripheral antitussive, with no action in thecentral nervous system.[1] It does not causeside effects such asconstipation orrespiratory depression which can be produced byopioid antitussives such ascodeine and its derivatives.

Levopront

In September 2021, Korea United Pharm file lawsuits against 15 drug manufacturers aspatent infringement protection for its 2017 registeredantitussive drug Levotics CR Tab. (levodropropizine). The cases are anchored on violation of its patent for "Method for Preparing Sustained-Release Tablets Containing Levodropropizine."[2] In September 2023, KUP signed a five-year $52.1 million contract with MCQ, a Thai-based pharmaceutical company, for supply of itsmucoactive drug, Levotics CR Tab (levodropropizine).[3]

References

[edit]
  1. ^De Blasio F, Dicpinigaitis PV, Rubin BK, De Danieli G, Lanata L, Zanasi A (January 2012)."An observational study on cough in children: epidemiology, impact on quality of sleep and treatment outcome".Cough.8 (1): 1.doi:10.1186/1745-9974-8-1.PMC 3274450.PMID 22269875.
  2. ^Chan-hyuk, Kim (September 9, 2021)."Korea United Pharm sues 15 drugmakers to protect cough suppressant's patent".Korea Biomedical Review. RetrievedJuly 29, 2024.
  3. ^"Korea United Pharm to supply mucoactive drugs worth $52 million to Thailand".Korea Biomedical Review. September 9, 2023. RetrievedJuly 29, 2024.

External links

[edit]
Phenylpiperazines
Benzylpiperazines
Naphthylpiperazines
Quinolinylpiperazines
Diphenylalkylpiperazines
Pyrimidinylpiperazines
Pyridinylpiperazines
Benzo(iso)thiazolylpiperazines
Tricyclic-linked piperazines
Others/uncategorized
Expectorants
Mucolytics
Cough suppressants
Opium alkaloids,
opioids,
and derivatives
Other


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