KLK9 belongs to thekallikrein subgroup ofserine proteases, which have diverse physiologic functions in many tissues.[6][7][8] KLK9 is primarily expressed in thymus, testis, spinal cord, cerebellum, trachea, mammary gland, prostate, brain, salivary gland, ovary, and skin.[5]
KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines and is a potential prognostic marker for early-stageovarian[9] andbreast cancer patients.[10]
^Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, et al. (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins".Biological Chemistry.387 (6):637–641.doi:10.1515/BC.2006.082.PMID16800724.S2CID436200.
^"Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005".Biological Chemistry.387 (6):635–824. June 2006.doi:10.1515/BC.2006.081.PMID16800723.S2CID83910246.
^Yousef GM, Scorilas A, Nakamura T, Ellatif MA, Ponzone R, Biglia N, et al. (March 2003). "The prognostic value of the human kallikrein gene 9 (KLK9) in breast cancer".Breast Cancer Research and Treatment.78 (2):149–158.doi:10.1023/A:1022931403825.PMID12725415.S2CID6515644.
Yousef GM, Kyriakopoulou LG, Scorilas A, Fracchioli S, Ghiringhello B, Zarghooni M, et al. (November 2001). "Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker".Cancer Research.61 (21):7811–7818.PMID11691797.
Yousef GM, Luo LY, Diamandis EP (1999). "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4".Anticancer Research.19 (4B):2843–2852.PMID10652563.
Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, et al. (October 2000). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region".Gene.257 (1):119–130.doi:10.1016/S0378-1119(00)00382-6.PMID11054574.
