Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

KCNK7

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
KCNK7
Identifiers
AliasesKCNK7, K2p7.1, TWIK3, potassium two pore domain channel subfamily K member 7
External IDsOMIM:603940;MGI:1341841;HomoloGene:43131;GeneCards:KCNK7;OMA:KCNK7 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for KCNK7
Genomic location for KCNK7
Band11q13.1Start65,592,836bp[1]
End65,595,996bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for KCNK7
Genomic location for KCNK7
Band19|19 AStart5,754,395bp[2]
End5,757,137bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of abdomen

  • skin of leg

  • skin of arm

  • human penis

  • nipple

  • vulva

  • gingival epithelium

  • skin of thigh

  • skin of hip

  • vagina
Top expressed in
  • lip

  • esophagus

  • skin of external ear

  • embryo

  • granulocyte

  • embryo

  • embryo

  • ganglion cell layer

  • hair follicle

  • skin of back
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10089

16530

Ensembl

ENSG00000173338

ENSMUSG00000024936

UniProt

Q9Y2U2

Q9Z2T1

RefSeq (mRNA)

NM_033456
NM_005714
NM_033347
NM_033348
NM_033455

NM_001004138
NM_010609

RefSeq (protein)

NP_005705
NP_203133
NP_203134
NP_258416

NP_034739

Location (UCSC)Chr 11: 65.59 – 65.6 MbChr 19: 5.75 – 5.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium channel, subfamily K, member 7, also known asKCNK7 orK2P7.1 is aprotein which is encoded in humans by theKCNK7gene. K2P7.1 is apotassium channel containing two pore-forming P domains.[5][6][7] Multiple transcript variants encoding different isoforms have been found for this gene.[8]

Function

[edit]

This gene encodes a member of the superfamily ofpotassium channel proteins containingtwo pore-forming P domains. The product of this gene has not been shown to be a functional channel; It may require other non-pore-forming proteins for activity.[8]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000173338Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000024936Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M (April 1999)."Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure".J. Biol. Chem.274 (17):11751–60.doi:10.1074/jbc.274.17.11751.PMID 10206991.
  6. ^Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (March 2001)."Potassium leak channels and the KCNK family of two-P-domain subunits".Nat. Rev. Neurosci.2 (3):175–84.doi:10.1038/35058574.PMID 11256078.S2CID 9682396.
  7. ^Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005)."International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels".Pharmacol. Rev.57 (4):527–40.doi:10.1124/pr.57.4.12.PMID 16382106.S2CID 7356601.
  8. ^ab"Entrez Gene: potassium channel".

Further reading

[edit]

External links

[edit]
Ligand-gated
Voltage-gated
Constitutively active
Proton-gated
Voltage-gated
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl:Chloride channel
H+:Proton channel
M+:CNG cation channel
M+:TRP cation channel
H2O (+solutes):Porin
Cytoplasm:Gap junction
By gating mechanism
Ion channel class
see alsodisorders


Stub icon

Thismembrane protein–related article is astub. You can help Wikipedia byadding missing information.

Retrieved from "https://en.wikipedia.org/w/index.php?title=KCNK7&oldid=1301324544"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2026 Movatter.jp