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| Names | |
|---|---|
| Preferred IUPAC name 2-(2-Methylphenyl)-1-(1-pentyl-1H-indol-3-yl)ethan-1-one | |
| Identifiers | |
3D model (JSmol) | |
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| Properties | |
| C22H25NO | |
| Molar mass | 319.448 g·mol−1 |
| Pharmacology | |
| Legal status | |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
JWH-251 (1-pentyl-3-(2-methylphenylacetyl)indole) is asynthetic cannabinoid from thephenylacetylindole family, which acts as acannabinoid agonist with about five times selectivity forCB1 with aKi of 29 nM and 146 nM atCB2. Similar to the related 2'-methoxy compoundJWH-250, the 2'-chloro compoundJWH-203, and the 2'-bromo compoundJWH-249, JWH-251 has aphenylacetyl group in place of thenaphthoyl ring used in mostaminoalkylindole cannabinoid compounds.[3][4]
In the United States, all CB1 receptor agonists of the 3-phenylacetylindole class such as JWH-251 areSchedule I Controlled Substances.[5]
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