HNRNPK
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 1J5K,1KHM,1ZZI,1ZZJ,1ZZK
Identifiers
Aliases	HNRNPK, CSBP, HNRPK, TUNP, AUKS, heterogeneous nuclear ribonucleoprotein K
External IDs	OMIM:600712;MGI:99894;HomoloGene:81909;GeneCards:HNRNPK;OMA:HNRNPK - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q21.32 Start 83,968,083bp[1] End 83,980,616bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 58,391,142bp[2] End 58,403,343bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ventricular zone ganglionic eminence appendix monocyte right uterine tube smooth muscle tissue left ovary right lobe of thyroid gland left lobe of thyroid gland Top expressed in tail of embryo genital tubercle ventricular zone neural tube epiblast ovary mesencephalon ganglionic eminence spermatocyte neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding nucleic acid binding DNA binding single-stranded DNA binding RNA binding cadherin binding protein domain specific binding identical protein binding Cellular component cytoplasm membrane focal adhesion nucleus catalytic step 2 spliceosome cell projection extracellular exosome podosome spliceosomal complex cell junction extracellular matrix nucleoplasm cytoplasmic stress granule Biological process positive regulation of receptor-mediated endocytosis regulation of transcription by RNA polymerase II negative regulation of mRNA splicing, via spliceosome regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of transcription, DNA-templated transcription, DNA-templated viral process RNA processing mRNA processing regulation of low-density lipoprotein particle clearance mRNA splicing, via spliceosome signal transduction positive regulation of transcription by RNA polymerase II negative regulation of apoptotic process RNA splicing transcription by RNA polymerase II RNA metabolic process Sources:Amigo /QuickGO
Orthologs Species Human Mouse Entrez 3190 15387 Ensembl ENSG00000165119 ENSMUSG00000021546 UniProt P61978 P61979 RefSeq (mRNA) NM_002140 NM_031262 NM_031263 NM_001318186 NM_001318187 NM_001318188 NM_001301340 NM_001301341 NM_001301343 NM_001301344 NM_001301345 NM_025279 RefSeq (protein) NP_001305115 NP_001305116 NP_001305117 NP_002131 NP_112552 NP_112553 NP_001288269 NP_001288270 NP_001288272 NP_001288273 NP_001288274 NP_079555 NP_001347419 NP_001347420 NP_001347422 NP_001347423 NP_001347424 Location (UCSC) Chr 9: 83.97 – 83.98 Mb Chr 13: 58.39 – 58.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Heterogeneous nuclear ribonucleoprotein K (alsoprotein K) is aprotein that in humans is encoded by theHNRNPKgene.^[5] It is found in thecell nucleus that binds to pre-messenger RNA (mRNA) as a component ofheterogeneous ribonucleoprotein particles. Thesimianhomolog is known asprotein H16. Both proteins bind to single-strandedDNA as well as toRNA and can stimulate the activity ofRNA polymerase II, the protein responsible for mostgene transcription. The relative affinities of the proteins for DNA and RNA vary with solution conditions and are inversely correlated, so that conditions promoting strong DNA binding result in weak RNA binding.^[6]

RNA binding protein domains in other proteins that are similar to the RNA binding domain of protein K are calledK-homology orKH domains.

Protein K has been the subject of study related tocolorectal cancer, in which anRNA editing event inducing theexpression of anisoform containing apoint mutation was found to be specific to cancerous cells.^[7]

This gene belongs to the subfamily of ubiquitously expressedheterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs areRNA-binding proteins, and they complex withheterogeneous nuclear RNA (hnRNA). These proteins are associated withpre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects ofmRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm.

The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in thenucleoplasm and has three repeats ofKH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progression. Multiple alternatively spliced transcript variants have been described for this gene, but only three variants have been fully described.^[8]

Mutations in both copies ofHNRNPK are embryonic lethal in mice. Mice with both copies of the gene knocked out die before the 14th day ofembryonic development.^[9]

Mutations inHNRNPK causeOkamoto syndrome, also known as Au–Kline syndrome.^[10]

Deletions in the region encompassingHNRNPK have been found in the cells ofacute myeloid leukemia in approximately 2% of cases. Additionally, a majority of mice who have had one of theirHNRNPK genes artificiallyknocked out developedmyeloid cancers, with a third developinglymphoid cancers and 4% developinghepatocellular carcinomas. The mice were also smaller, had less developed organs and had higher postnatal mortality (30%). The median lifespan of the mice that survived was less than 50% that of wild-type mice. Deficiencies in HNRNPK appear to specifically reduce the levels of the p42isoform ofCEBPA, which is atranscription factor involved in the differentiation of certainblood cells, as well asp21 (cyclin-dependent kinase inhibitor 1), which is involved in pausing cell development forDNA repair.^[11]

HNRNPK overexpression also appears to contribute to cancers via a different mechanism involvingtranslation rather thantranscription.^[11]

HNRPK has been shown tointeract with:

• CSK,^[12]
• DDX1,^[13]
• HNRNPL,^[14]
• KHDRBS1,^[15]
• PCBP2,^[14]
• PRMT1,^[16][17] and
• PTBP1.^[14]

AKAP1;ANKHD1;ANKRD17;ASCC1;BICC1;DDX43;DDX53;DPPA5;FMR1;FUBP1;FUBP3;FXR1;FXR2;HDLBP;HNRPK;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;KRR1;MEX3A;MEX3B;MEX3C;MEX3D;NOVA1;NOVA2;PCBP1;PCBP2;PCBP3;PCBP4;PNO1;PNPT1;QKI;SF1;TDRKH;

• Overview of all the structural information available in thePDB forUniProt:P61978 (Human Heterogeneous nuclear ribonucleoprotein K (HNRPK)) at thePDBe-KB.

• Genes on human chromosome 9
• RNA-binding proteins

• Articles with short description
• Short description is different from Wikidata