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GPR115

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

ADGRF4

Identifiers

Aliases

ADGRF4, PGR18, GPR115, adhesion G protein-coupled receptor F4

External IDs

OMIM:614268;MGI:1925499;HomoloGene:51953;GeneCards:ADGRF4;OMA:ADGRF4 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p12.3	Start	47,685,864bp^[1]
Band	6p12.3	End	47,722,021bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 B3	Start	42,967,782bp^[2]
Band	17\|17 B3	End	43,003,175bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

skin of abdomen

skin of leg

skin of arm

gingival epithelium

human penis

right uterine tube

amniotic fluid

skin of thigh

vagina

oral cavity

Top expressed in

decidua

skin of external ear

gastrula

molar

skin of abdomen

skin of back

embryo

epidermis

hair follicle

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity
Cellular component	integral component of membrane membrane
Biological process	G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


221393


78249

Ensembl


ENSG00000153294


ENSMUSG00000023918

UniProt


Q8IZF3


Q9D2L6

RefSeq (mRNA)


NM_153838 NM_001347855


NM_001289499 NM_001289500 NM_001289501 NM_030067

RefSeq (protein)


NP_001334784 NP_722580


NP_001276428 NP_001276429 NP_001276430 NP_084343

Location (UCSC)

Chr 6: 47.69 – 47.72 Mb

Chr 17: 42.97 – 43 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Probable G-protein coupled receptor 115 is aprotein that in humans is encoded by theGPR115gene.^[5]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000153294 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000023918 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002)."Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions".FEBS Lett.531 (3):407–14.doi:10.1016/S0014-5793(02)03574-3.PMID 12435584.S2CID 7449692.
^"Entrez Gene: GPR115 G protein-coupled receptor 115".

Bonaldo MF, Lennon G, Soares MB (1997)."Normalization and subtraction: two approaches to facilitate gene discovery".Genome Res.6 (9):791–806.doi:10.1101/gr.6.9.791.PMID 8889548.
Vassilatis DK, Hohmann JG, Zeng H, et al. (2003)."The G protein-coupled receptor repertoires of human and mouse".Proc. Natl. Acad. Sci. U.S.A.100 (8):4903–8.Bibcode:2003PNAS..100.4903V.doi:10.1073/pnas.0230374100.PMC 153653.PMID 12679517.
Mungall AJ, Palmer SA, Sims SK, et al. (2003)."The DNA sequence and analysis of human chromosome 6".Nature.425 (6960):805–11.Bibcode:2003Natur.425..805M.doi:10.1038/nature02055.PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors".Genomics.84 (1):23–33.doi:10.1016/j.ygeno.2003.12.004.PMID 15203201.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16 (1):55–65.doi:10.1101/gr.4039406.PMC 1356129.PMID 16344560.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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