Fluralaner (INN),[12] sold under the brand nameBravecto among others, is a systemicinsecticide andacaricide that is administered orally[13] or topically.[14]
Fluralaner inhibitsγ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) and L-glutamate-gated chloride channels (GluCls).[15] Potency of fluralaner is comparable tofipronil (a related GABA-antagonist insecticide and acaricide).[16]
The USFood and Drug Administration (FDA) approved it for flea treatment in dogs in May 2014,[17] and approved the combinationfluralaner/moxidectin (Bravecto Plus) as a topical treatment for cats in November 2019.[18][19][20][21] The EU approved fluralaner in March 2014.[5][6][22] Australia approved it for the treatment and prevention of ticks and fleas on dogs in January 2015.[23] For treating mites in chickens, a solution for use in drinking water is available under the brand name Exzolt[24] and was approved for use in the EU in 2017.[25]
Bravecto 1-Month was approved by the FDA in November 2024 for the addition of the indication for the treatment and control ofHaemaphysalis longicornis (Asian longhorned tick) infestations for one month in dogs and puppies eight weeks of age and older, and weighing 4.4 pounds (2.0 kg) or greater.[26][27]
In June 2025, theCommittee for Veterinary Medicinal Products of theEuropean Medicines Agency adopted a positive opinion, recommending the granting of a marketing authorization for the veterinary medicinal product Bravecto Combiuno chewable tablets intended for dogs.[28] The applicant for this veterinary medicinal product is Intervet International B.V.[28] Bravecto Combiuno is an antiparasitic medicinal product containing fluralaner andmilbemycin oxime as active substances. Both substances exert parasiticidal activity by interacting with ligand-gated ion channels in the nervous system of various parasites such as insects, acari and helminths.[28]
^Asahi M, Kobayashi M, Matsui H, Nakahira K (January 2015). "Differential mechanisms of action of the novel γ-aminobutyric acid receptor antagonist ectoparasiticides fluralaner (A1443) and fipronil".Pest Management Science.71 (1):91–95.Bibcode:2015PMSci..71...91A.doi:10.1002/ps.3768.PMID24591229.
^"Agricultural and Veterinary Chemicals"(PDF). Australian Pesticides and Veterinary Medicines Authority. 10 February 2015.Archived(PDF) from the original on 19 September 2022. Retrieved14 February 2019.
^abc"Bravecto CombiUNO EPAR".European Medicines Agency (EMA). 13 June 2025. Retrieved15 June 2025. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
This article incorporates text from this source, which is in thepublic domain.