Edward Lewis ForMemRS | |
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| Born | Edward Butts Lewis May 20, 1918 (1918-05-20) |
| Died | July 21, 2004(2004-07-21) (aged 86) Pasadena, California, US |
| Education |
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| Known for | Research into genetics of thecommon fruit fly |
| Awards | |
| Scientific career | |
| Fields | |
| Thesis | A genetic and cytological analysis of a tandem duplication and its included loci in Drosophila melanogaster (1942) |
| Doctoral advisor | Alfred Sturtevant |
| Doctoral students | Mark M. Davis[2] |
Edward Butts Lewis (May 20, 1918 – July 21, 2004) was an Americangeneticist, a corecipient of the 1995Nobel Prize in Physiology or Medicine.[3][4][5][6][7][8] He helped to found the field ofevolutionary developmental biology.
Lewis was born inWilkes-Barre, Pennsylvania, the second son of Laura Mary Lewis (née Histed) and Edward Butts Lewis, a watchmaker-jeweler. His full name was supposed to be Edward Butts Lewis Jr., but his birth certificate was incorrectly filled out with "B." as his middle name.[9]
Lewis graduated fromE. L. Meyers High School.[10]
He received a BA in Biostatistics from theUniversity of Minnesota in 1939, where he worked onDrosophila melanogaster in the lab ofC.P. Oliver. In 1942 Lewis received a PhD fromCalifornia Institute of Technology (Caltech), working under the guidance ofAlfred Sturtevant. In 1939, Edward B. Lewis arrived at Caltech and finished his PhD within three years. Lewis enrolled in the U.S. Army Air Corps training program in meteorology in 1942 and later received his master's degree in the area a year later. As he left for military service in 1943, he was told by the university president Robert A. Millikan that he had a position as an instructor at Caltech when he returned. He served working mostly as a weather forecaster in Hawaii and Okinawa for four years. Lewis returned in 1946 and took his position at Caltech where his duties included helping in the laboratory for an introductory genetics course. He was promoted in 1956 to a professor and became the Thomas Hunt Morgan Professor of Biology in 1966.[3]
In 1946, Edward B. Lewis met Pamela Harrah (1925–2018). She was an accomplished artist, but also shared Lewis' interests in animal life. She had gone to Stanford and studied genetics and later discovered the mutantPolycomb, that now is important in the understanding of gene regulation. They married and had three sons named Glenn, Hugh, and Keith. Pam developed an infection that caused her to have a visual and physical, partial unilateral paralysis, which limited her mobility.[11]
Lewis maintained a constant exercise routine in his day, as he started his mornings with breakfast and exercise, until he suffered from cancer. Lewis would normally have lunch with his faculty members at the Anthenaeum, then take a nap and return to the laboratory in the evening. The most constant part of his daily routine was that he would do most of his work at night. He also enjoyed playing the flute and would allow himself to have time to play the flute at night. In addition, Lewis appreciated other aspects of life even though they interrupted his typical schedule. Some other things he did with his time include: jogging, swimming, playing on the beach, playing chamber music with friends, going to see movies, and attending opera performances. Edward B. Lewis was a humble man who did not always receive attention for his works. Over time, his work withDrosophila became more appreciated and he began to attract more attention.[11]
His Nobel Prize–winning studies withDrosophila, (including the discovery[12] of theDrosophilaBithorax complex ofhomeotic genes, and elucidation of its function), founded the field ofevolutionary developmental biology and laid the groundwork for our current understanding of the universal, evolutionarily conserved strategies controlling animal development. He is credited with development of thecomplementation test. His key publications in the fields ofgenetics,developmental biology,radiation and cancer are presented in the bookGenes, Development and Cancer, which was released in 2004.
During the 1950s, Lewis studied the effects of radiation fromX-rays,nuclear fallout and other sources as possible causes of cancer. He reviewed medical records from survivors of theatomic bombings of Hiroshima and Nagasaki, as well as radiologists and patients exposed to X-rays. Lewis concluded that "health risks from radiation had been underestimated". Lewis published articles inScience and other journals and made a presentation to a Congressional committee on atomic energy in 1957.[13]
At the scientific level of the debate, the crucial question was whether the "threshold theory" was valid or whether, as Lewis insisted, the effects of radioactivity were "linear with no threshold", where every exposure to radiation had a long-term cumulative effect.[14]
The issue of linearity versus threshold re-entered the debate on nuclear fallout in 1962, whenErnest Sternglass, a Pittsburgh physicist, argued that the linearity thesis was confirmed by the research ofAlice Stewart.[15] (See alsoJohn Gofman )
On November 20, 2001, Lewis was interviewed byElliot Meyerowitz in the Kerckhoff Library at the California Institute of Technology, Pasadena, California. This interview was released on DVD in 2004 as "Conversations in Genetics: Volume 1, No. 3 – Edward B. Lewis; An Oral History of Our Intellectual Heritage in Genetics" 67 min; Producer Rochelle Easton Esposito; The Genetics Society of America.
including the Nobel Lecture on December 8, 1995The Bithorax Complex: The First Fifty Years| International | |
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