ERB-26 is asyntheticestrogen and aselectiveagonist of theERβ.^[1][2] It is theactiveenantiomer of theracemic mixtureERB-79.^[1] Whereas ERB-79 shows 484-fold selectivity for the ERβ over the ERα,^[3] ERB-26 differs slightly in that it is even more selective, showing greater than 1,000-fold selectivity fortransactivation of the ERβ relative to the ERα.^[1] ItsEC₅₀ value for the ERβ is 0.21 nM (4-fold weaker thanestradiol) and for the ERα is 260 nM (10,000-fold weaker than estradiol).^[1] It has noantagonistic activity at either receptor.^[1] ERB-26 is active in prevention ofprostate cancer development inpreclinicalmodels.^[1] In contrast to ERB-26, the selective ERα agonistERA-45 induced prostate cancer development in preclinical models when it was given in combination withtestosterone, whereas testosterone alone did not do so.^[1] These findings suggest opposing roles of the ERα and ERβ in theprostate gland.^[1] Thechemical structure of ERB-26 does not appear to have been disclosed.

• Diarylpropionitrile
• ERB-196
• Erteberel
• FERb 033
• Prinaberel (ERB-041)
• WAY-166818
• WAY-200070
• WAY-214156

Thisdrug article relating to thegenito-urinary system is astub. You can help Wikipedia byadding missing information.

• v
• t
• e

• Drugs with undisclosed chemical structures
• Selective ERβ agonists
• Synthetic estrogens
• Genito-urinary system drug stubs

• Articles with short description
• Short description matches Wikidata
• Short description is different from Wikidata
• Infobox drug articles without a structure image
• Chemical articles without CAS registry number
• Articles without EBI source
• Chemical pages without ChemSpiderID
• Chemical pages without DrugBank identifier
• Articles without KEGG source
• Articles without InChI source
• Articles without UNII source
• Drugs missing an ATC code
• Drugs with no legal status
• Articles containing unverified chemical infoboxes
• All stub articles