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| ECHA InfoCard | 100.201.022 |
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| Formula | C25H38O3 |
| Molar mass | 386.576 g·mol−1 |
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Dexanabinol (HU-211 orETS2101[1]) is asynthetic cannabinoid derivative in development by e-Therapeutics plc[2]. It is the "unnatural"enantiomer of the potent cannabinoid agonistHU-210.[3] Unlike othercannabinoid derivatives, HU-211 does not act as acannabinoid receptor agonist, but instead as anNMDA antagonist.[4] It therefore does not produce cannabis-like effects, but isanticonvulsant andneuroprotective, and is widely used in scientific research as well as currently being studied for applications such as treating head injury, stroke, or cancer.[5][6][7] It was shown to be safe inclinical trials[8] and is currently undergoingPhase I trials for the treatment ofbrain cancer[9] and advanced solid tumors.[10]
Dexanabinol has been studied in IV administration and oral dosing.[11] e-Therapeutics is evaluating the compound in clinical trials for brain and solid cancers.[12] Phase II studies are planned based on the results of the current trials.
A phase 1b study for hepatocellular carcinoma and pancreatic cancer was started in 2015.[13]
HU-211 is not listed in the schedules set out by theUnited Nations'Single Convention on Narcotic Drugs from 1961 nor theirConvention on Psychotropic Substances from 1971,[14] so the signatory countries to these international drug control treaties are not required by said treaties to control HU-211.
HU-211 is not listed in thelist of scheduled controlled substances in the USA.[15] It is therefore notscheduled at thefederal level in theUnited States, but it is possible that HU-211 could legally be considered ananalog of Delta-8-THC (one of the THC isomers which is in Schedule I under the designation of "Tetrahydrocannabinols"), and therefore sales orpossession could potentially be prosecuted under theFederal Analogue Act.[16]
HU-211 is a Schedule I controlled substance inAlabama.[17]
HU-211 is a Schedule Icontrolled substance in the state ofFlorida making it illegal to buy, sell, or possess in Florida.[18]
Effective January 1, 2016, HU-211 is a regulated drug in Vermont designated as a "Hallucinogenic Drug."[19]