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Deschloroketamine

From Wikipedia, the free encyclopedia
Chemical compound
"DXE" redirects here. For other uses, seeDXE (disambiguation).

Pharmaceutical compound
Deschloroketamine
Legal status
Legal status
Identifiers
  • 2-Phenyl-2-(methylamino)cyclohexanone
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC13H17NO
Molar mass203.285 g·mol−1
3D model (JSmol)
  • CNC1(CCCCC1=O)c2ccccc2
  • InChI=1S/C13H17NO/c1-14-13(10-6-5-9-12(13)15)11-7-3-2-4-8-11/h2-4,7-8,14H,5-6,9-10H2,1H3
  • Key:ZAGBSZSITDFFAF-UHFFFAOYSA-N

Deschloroketamine (DXE, DCK, 2'-Oxo-PCM) is adissociativeanesthetic[1][2] that has been sold online as adesigner drug.[3][4][5][6][7] It has also been proposed for the treatment of bacterial, fungal, viral or protozoal infections and for immunomodulation at doses of 2 mg per day.[8]

Legal status

[edit]

Deschloroketamine is illegal in Latvia.[9]

See also

[edit]

References

[edit]
  1. ^Robins EG, Zhao Y, Khan I, Wilson A, Luthra SK, Rstad E (March 2010). "Synthesis and in vitro evaluation of (18)F-labelled S-fluoroalkyl diarylguanidines: Novel high-affinity NMDA receptor antagonists for imaging with PET".Bioorganic & Medicinal Chemistry Letters.20 (5):1749–51.doi:10.1016/j.bmcl.2010.01.052.PMID 20138515.
  2. ^US 3254124, Stevens CL, "Aminoketones and methods for their production", published 31 May 1966 
  3. ^Frison G, Zamengo L, Zancanaro F, Tisato F, Traldi P (January 2016)."Characterization of the designer drug deschloroketamine (2-methylamino-2-phenylcyclohexanone) by gas chromatography/mass spectrometry, liquid chromatography/high-resolution mass spectrometry, multistage mass spectrometry, and nuclear magnetic resonance".Rapid Communications in Mass Spectrometry.30 (1):151–60.Bibcode:2016RCMS...30..151F.doi:10.1002/rcm.7425.PMID 26661982.
  4. ^"Alerta: descloroketamina vendida como ketamina en Barcelona" (in Spanish). Energy Control. Retrieved2 October 2015.
  5. ^Villalba J (27 March 2015)."Los efectos desconocidos de la sequía de ketamina" (in Spanish). Vice. Retrieved2 October 2015.
  6. ^Knibbs J (22 October 2015)."Party-drug testing shows its worth". The Medical Republic.
  7. ^Hájková K, Jurásek B, Čejka J, Štefková K, Páleníček T, Sýkora D, Kuchař M (October 2019). "Synthesis and identification of deschloroketamine metabolites in rats' urine and a quantification method for deschloroketamine and metabolites in rats' serum and brain tissue using liquid chromatography tandem mass spectrometry".Drug Testing and Analysis.12 (3):343–360.doi:10.1002/dta.2726.PMID 31670910.S2CID 204975994.
  8. ^DE 4409671, Preiss D, Tatar A, "Use of 2-methylamino-2-phenylcyclohexanone for the treatment of bacterial, fungal, viral or protozoal infections and for immunomodulation", published 23 May 1995 
  9. ^"Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem" [Regulations on Narcotic Drugs, Psychotropic Substances and Precursors Controlled in Latvia] (in Latvian). Ministry of Health of the Republic of Latvia. Archived fromthe original on 4 March 2016. Retrieved29 October 2015.
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