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Cyclic nucleotide-gated channel alpha 1

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

CNGA1

Identifiers

Aliases

CNGA1, CNCG, CNCG1, CNG-1, CNG1, RCNC1, RCNCa, RCNCalpha, RP49, Cyclic nucleotide-gated channel alpha 1, cyclic nucleotide gated channel alpha 1, cyclic nucleotide gated channel subunit alpha 1

External IDs

OMIM:123825;MGI:88436;HomoloGene:55432;GeneCards:CNGA1;OMA:CNGA1 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4p12	Start	47,935,977bp^[1]
Band	4p12	End	48,016,681bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5 C3.2\|5 38.44 cM	Start	72,761,039bp^[2]
Band	5 C3.2\|5 38.44 cM	End	72,801,618bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

amniotic fluid

right lobe of liver

sural nerve

pancreatic epithelial cell

testicle

pancreatic ductal cell

mucosa of urinary bladder

skin of abdomen

skin of hip

corpus epididymis

Top expressed in

neural layer of retina

retinal pigment epithelium

epithelium of lens

ciliary body

iris

thymus

corneal stroma

zygote

conjunctival fornix

secondary oocyte

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding intracellular cyclic nucleotide activated cation channel activity ion channel activity protein binding voltage-gated potassium channel activity cGMP binding intracellular cAMP-activated cation channel activity intracellular cGMP-activated cation channel activity
Cellular component	integral component of membrane membrane plasma membrane photoreceptor outer segment integral component of plasma membrane photoreceptor outer segment membrane
Biological process	response to stimulus regulation of rhodopsin mediated signaling pathway regulation of membrane potential ion transport cation transmembrane transport transmembrane transport visual perception rhodopsin mediated signaling pathway potassium ion transmembrane transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


1259


12788

Ensembl


ENSG00000198515


ENSMUSG00000067220

UniProt


P29973


P29974

RefSeq (mRNA)


NM_000087 NM_001142564 NM_001379270


NM_007723

RefSeq (protein)


NP_000078 NP_001136036 NP_001366199 NP_000078.2


NP_031749

Location (UCSC)

Chr 4: 47.94 – 48.02 Mb

Chr 5: 72.76 – 72.8 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cyclic nucleotide-gated channel alpha 1, also known asCNGA1, is a humangene encoding anion channel protein.^[5] Heterologously expressed CNGA1 can form a functional channel that is permeable to calcium.^[6] Inrod photoreceptors, however, CNGA1 forms a heterotetramer with CNGB1 in a 3:1 ratio.^[7]^[8]^[9] The addition of theCNGB1 channel imparts altered properties including more rapid channel kinetics and greater cAMP-activated current.^[10] When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/B1 channels and, therefore,hyperpolarization of the membrane potential.

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000198515 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000067220 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: CNGA1 cyclic nucleotide gated channel alpha 1".Ncbi.nlm.nih.gov. Retrieved2016-08-02.
^Kaupp UB, Niidome T, Tanabe T, Terada S, Bonigk W, Stuhmer W, et al. (December 1989). "Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel".Nature.342 (6251):762–766.Bibcode:1989Natur.342..762K.doi:10.1038/342762a0.hdl:11858/00-001M-0000-002B-B7A4-3.ISSN 0028-0836.PMID 2481236.S2CID 4254661.
^Zheng J, Trudeau MC, Zagotta WN (December 2002)."Rod Cyclic Nucleotide-Gated Channels Have a Stoichiometry of Three CNGA1 Subunits and One CNGB1 Subunit".Neuron.36 (5):891–896.doi:10.1016/s0896-6273(02)01099-1.ISSN 0896-6273.PMID 12467592.S2CID 15365006.
^Zhong H, Molday LL, Molday RS, Yau KW (November 2002)."The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry".Nature.420 (6912):193–198.Bibcode:2002Natur.420..193Z.doi:10.1038/nature01201.ISSN 0028-0836.PMC 2877395.PMID 12432397.
^Weitz D, Ficek N, Kremmer E, Bauer PJ, Kaupp UB (December 2002)."Subunit Stoichiometry of the CNG Channel of Rod Photoreceptors".Neuron.36 (5):881–889.doi:10.1016/s0896-6273(02)01098-x.ISSN 0896-6273.PMID 12467591.S2CID 17176092.
^Chen TY, Peng YW, Dhallan RS, Ahamed B, Reed RR, Yau KW (April 1993). "A new subunit of the cyclic nucleotide-gated cation channel in retinal rods".Nature.362 (6422):764–767.Bibcode:1993Natur.362..764C.doi:10.1038/362764a0.ISSN 0028-0836.PMID 7682292.S2CID 4350775.

External links

[edit]

GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview
CNGA1+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Membrane transport protein:ion channels (TC 1A)

Ca²⁺:Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺:Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺:Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻:Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺:Proton channel	HVCN1
M⁺:CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺:TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+solutes):Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm:Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin