Carbonic anhydrase 5B, mitochondrial is anenzyme that in humans is encoded by theCA5Bgene.[5][6]
Carbonic anhydrases (CAs) are a large family ofzincmetalloenzymes that catalyze the reversible hydration ofcarbon dioxide. They participate in a variety of biological processes, includingrespiration,calcification,acid-base balance,bone resorption, and the formation ofaqueous humor,cerebrospinal fluid,saliva, andgastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in themitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to theliver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles.[6]
Vullo D, Nishimori I, Innocenti A, et al. (2007). "Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines".Bioorg. Med. Chem. Lett.17 (5):1336–40.doi:10.1016/j.bmcl.2006.11.075.PMID17174092.
