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CLIC2

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From Wikipedia, the free encyclopedia

Protein-coding gene in humans

CLIC2

Available structures

PDB

Human UniProt search:PDBe RCSB

List of PDB id codes
2PER,2R4V,2R5G

Identifiers

Aliases

CLIC2, CLIC2b, MRXS32, XAP121, chloride intracellular channel 2, CLCNL2

External IDs

OMIM:300138;HomoloGene:48010;GeneCards:CLIC2;OMA:CLIC2 - orthologs

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xq28	Start	155,276,211bp^[1]
Band	Xq28	End	155,334,657bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

epithelium of colon

right lung

spleen

upper lobe of left lung

gallbladder

superficial temporal artery

lymph node

left lobe of thyroid gland

right lobe of thyroid gland

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	glutathione transferase activity voltage-gated ion channel activity glutathione peroxidase activity protein binding chloride channel activity
Cellular component	cytoplasm integral component of membrane membrane intracellular anatomical structure chloride channel complex nucleus
Biological process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of ion transmembrane transport ion transport negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of binding chloride transport regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum signal transduction cellular oxidant detoxification glutathione metabolic process chloride transmembrane transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


1193


n/a

Ensembl


ENSG00000155962


n/a

UniProt


O15247


n/a

RefSeq (mRNA)


NM_001289


n/a

RefSeq (protein)


NP_001280


n/a

Location (UCSC)

Chr X: 155.28 – 155.33 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Chloride intracellular channel protein 2 is aprotein that in humans is encoded by theCLIC2gene.^[3]^[4]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization ofcell membrane potential, transepithelial transport, maintenance ofintracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected infetal liver and adultskeletal muscle tissue. This gene maps to the candidate region onchromosome X forincontinentia pigmenti.^[4]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000155962 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Heiss NS, Poustka A (Nov 1997). "Genomic structure of a novel chloride channel gene, CLIC2, in Xq28".Genomics.45 (1):224–8.doi:10.1006/geno.1997.4922.PMID 9339381.
^^a ^b"Entrez Gene: CLIC2 chloride intracellular channel 2".

External links

[edit]

CLIC2+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
HumanCLIC2 genome location andCLIC2 gene details page in theUCSC Genome Browser.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Membrane transport protein:ion channels (TC 1A)

Ca²⁺:Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺:Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺:Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻:Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺:Proton channel	HVCN1
M⁺:CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺:TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+solutes):Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm:Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin