Protein-coding gene in humans
Charged multivesicular body protein 5 is aprotein that in humans is encoded by theCHMP5 gene .[ 4] [ 5] [ 6]
CHMP5 belongs to thechromatin -modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components ofESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs ). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP,CHMP1A , is required for both MVB formation and regulation ofcell cycle progression.[ 6] [ 7]
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