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CHF-1024

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Pharmaceutical compound
CHF-1024
Clinical data
Other namesCHF1024; 5,6-Dihydroxy-2-methylaminotetralin
Drug classDopamineD2 recpetoragonist;α2-Adrenergic receptoragonist
ATC code
  • None
Identifiers
  • 6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2-diol
CAS Number
PubChemCID
ChemSpider
UNII
Chemical and physical data
FormulaC11H15NO2
Molar mass193.246 g·mol−1
3D model (JSmol)
  • CNC1CCC2=C(C1)C=CC(=C2O)O
  • InChI=1S/C11H15NO2/c1-12-8-3-4-9-7(6-8)2-5-10(13)11(9)14/h2,5,8,12-14H,3-4,6H2,1H3
  • Key:BHDFPNRSDABMPW-UHFFFAOYSA-N

CHF-1024, also known as5,6-dihydroxy-2-methylaminotetralin, is adopamineD2 receptoragonist andα2-adrenergic receptor agonist of the2-aminotetralin family.[1][2] It is acyclized phenethylamineanalogue of theneurotransmitterdopamine.[1] The drug is the active form ofnolomirole (CHF-1035), aprodrug of CHF-1024 and theN,N-diisobutyryl diester of the compound.[1][2] Nolomirole was investigated for the treatment ofheart failure but was never marketed.[1][2]

See also

[edit]

References

[edit]
  1. ^abcdMealy NE, Leeson PA, Bayes M, Castaner J (2001)."Nolomirole Hydrochloride".Drugs of the Future.26 (11): 1046.doi:10.1358/dof.2001.026.11.642071. Retrieved19 June 2025.
  2. ^abcTang WH, Francis GS (November 2003). "Novel pharmacological treatments for heart failure".Expert Opinion on Investigational Drugs.12 (11):1791–1801.doi:10.1517/13543784.12.11.1791.PMID 14585055.


D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists
α1
Agonists
Antagonists
α2
Agonists
Antagonists
β
Agonists
Antagonists
Phenethylamines
Amphetamines
Phentermines
Cathinones
Phenylisobutylamines
(and further-extended)
Catecholamines
(and close relatives)
Cyclized
phenethylamines
Phenylalkylpyrrolidines
2-Benzylpiperidines
(phenidates)
Phenylmorpholines
(phenmetrazines)
Phenyloxazolamines
(aminorexes)
Isoquinolines and
tetrahydroisoquinolines
2-Aminoindanes
2-Aminotetralins
Others / unsorted
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