Chemokine (C-C motif) ligand 3 (CCL3) also known asmacrophage inflammatory protein 1-alpha (MIP-1-alpha) is aprotein that in humans is encoded by theCCL3gene.[5]
Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4).[7][5]
CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant humantumor necrosis factor or recombinant humaninterleukin-1. However, in contrast to these two endogenouspyrogens, the fever induced by MIP-1 is not inhibited by thecyclooxygenase inhibitoribuprofen and CCL3 may participate in thefebrile response that is not mediated throughprostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.[8]
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Joseph AM, Kumar M, Mitra D (Jan 2005). "Nef: "necessary and enforcing factor" in HIV infection".Current HIV Research.3 (1):87–94.doi:10.2174/1570162052773013.PMID15638726.
Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses".The Indian Journal of Medical Research.121 (4):270–86.PMID15817944.
