Ciechanover was born inHaifa, Mandatory Palestine on 1 October 1947[1] into aJewish family.[2] He is the son of Bluma (Lubashevsky), a teacher of English, and Yitzhak Ciechanover, an office worker in a law firm.[3] His parents immigrated to Israel from Poland in the 1920s.
Ciehanover, A., Hod, Y. and Hershko, A. (1978). A Heat-stable Polypeptide Component of an ATP-dependent Proteolytic System from Reticulocytes. Biochem. Biophys. Res. Commun. 81, 1100–1105. (His name was wrongly transliterated from Hebrew in this publication.)
Ciechanover, A., Heller, H., Elias, S., Haas, A.L. and Hershko, A. (1980). ATP-dependent Conjugation of Reticulocyte Proteins with the Polypeptide Required for Protein Degradation. Proc. Natl. Acad. Sci. USA 77, 1365–1368.
Hershko, A. and Ciechanover, A. (1982). Mechanisms of intracellular protein breakdown. Annu. Rev. Biochem. 51, 335–364.
Hershko, A. and Ciechanover, A. (1998). THE UBIQUITIN SYSTEM. Biochem. 1998 67:1, 425–479
Ciechanover was an invited guest lecturer at the Yerevan State Medical University in Armenia in 2010.
He lectured at the Pyongyang University of Science and Technology in North Korea in May 2016.
Ciechanover is a member of the advisory board ofPatient Innovation, a nonprofit, international, multilingual, free venue for patients and caregivers of any disease to share their innovations.
In 2004, he was awarded theNobel Prize inChemistry for his discovery withAvram Hershko andIrwin Rose, ofubiquitin-mediatedprotein degradation.[9][10] The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of cancer, muscular and neurological diseases, and immune and inflammatory responses.
Aaron Ciechanover on Nobelprize.org including the Nobel Lecture on December 8, 2004Intracellular Protein Degradation: From a Vague Idea thru the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting
