Acid-sensing ion channel 2 (ASIC2) also known asamiloride-sensitive cation channel 1, neuronal (ACCN1) orbrain sodium channel 1 (BNaC1) is aprotein that in humans is encoded by the ASIC2gene. The ASIC2 gene is one of the fiveparalogous genes that encode proteins that form trimericacid-sensing ion channels (ASICs) in mammals.[5] The cDNA of this gene was first cloned in 1996.[6][7][8][9] The ASIC genes have splicing variants that encode different proteins that are called isoforms.
These genes are mainly expressed in the central and peripheral nervous system.
ASICs can form both homotrimeric (meaning composed of three identical subunits) and heterotrimeric channels.[10][11]
This gene encodes a member of the ASIC/ENaC superfamily of proteins.[12] The members of this family areamiloride-sensitivesodium channels that containintracellular N and C termini, 2hydrophobictransmembrane (TM) regions, and a largeextracellular loop, which has manycysteine residues with conserved spacing. The TM regions are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus).
The pore of the channel through which ions selectively flow from the extracellular side into the cytoplasm is formed by the three TM2 regions of the trimer.[5]
^Waldmann R, Voilley N, Mattéï MG, Lazdunski M (Oct 1996). "The human degenerin MDEG, an amiloride-sensitive neuronal cation channel, is localized on chromosome 17q11.2-17q12 close to the microsatellite D17S798".Genomics.37 (2):269–70.doi:10.1006/geno.1996.0558.PMID8921408.
