Aquaporin-5 (AQP-5) is aprotein that in humans is encoded by theAQP5gene.[5][6]
Aquaporin-5 (AQP-5) is a water channel protein.Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-5 plays a role in the generation of saliva, tears and pulmonary secretions.[6] AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.[6]
AQP-5 features a homotetrameric structure embedded in the cell membrane with the center of each monomer acting as a water pore.[7] Each monomer structure is a transmembrane protein which have an asparagine–proline–alanine (NPA) hydrophobic residue embedded in the membrane of the cell. The NPA residue plays a role in water and solute permeability across the membrane of the cell.[7]
Ma T, Yang B, Umenishi F, Verkman AS (Aug 1997). "Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13".Genomics.43 (3):387–389.doi:10.1006/geno.1997.4836.PMID9268644.
Smith JK, Siddiqui AA, Modica LA, Dykes R, Simmons C, Schmidt J, et al. (Aug 1999). "Interferon-alpha upregulates gene expression of aquaporin-5 in humanparotid glands".Journal of Interferon & Cytokine Research.19 (8):929–935.doi:10.1089/107999099313479.PMID10476940.
Gresz V, Kwon TH, Hurley PT, Varga G, Zelles T, Nielsen S, et al. (Jul 2001). "Identification and localization of aquaporin water channels in human salivary glands".American Journal of Physiology. Gastrointestinal and Liver Physiology.281 (1):G247–G254.doi:10.1152/ajpgi.2001.281.1.G247.PMID11408278.
Chen Z, Wang X, Gao L, Bai L, Zhu R, Bai C (Apr 2006). "Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells".Biochemical and Biophysical Research Communications.342 (3):775–781.doi:10.1016/j.bbrc.2006.01.103.PMID16500622.
Pedersen PS, Braunstein TH, Jorgensen A, Larsen PL, Holstein-Rathlou NH, Frederiksen O (Mar 2007). "Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress".Pflügers Archiv: European Journal of Physiology.453 (6):777–785.doi:10.1007/s00424-006-0157-3.PMID17043812.S2CID6205954.
Skowron-zwarg M, Boland S, Caruso N, Coraux C, Marano F, Tournier F (Jul 2007). "Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation".Experimental Cell Research.313 (12):2695–2702.doi:10.1016/j.yexcr.2007.02.035.PMID17553491.
