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ABT-724

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
ABT-724
Identifiers
  • 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC17H19N5
Molar mass293.374 g·mol−1
3D model (JSmol)
  • n2c1ccccc1[nH]c2CN(CC4)CCN4c3ncccc3
  • InChI=1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20) checkY
  • Key:FRPJGTNLZNXQEX-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

ABT-724 is a drug which acts as adopamine agonist, and is selective for theD4 subtype.[1] It was developed as a possible drug for the treatment oferectile dysfunction,[2] although poor oral bioavailability means alternative drugs such asABT-670 may be more likely to be developed commercially.[3] Nonetheless, it continues to be used in scientific research into the function of the D4 receptor.[4][5]

See also

[edit]

References

[edit]
  1. ^Brioni JD, Moreland RB, Cowart M, Hsieh GC, Stewart AO, Hedlund P, et al. (April 2004)."Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats".Proceedings of the National Academy of Sciences of the United States of America.101 (17):6758–6763.Bibcode:2004PNAS..101.6758B.doi:10.1073/pnas.0308292101.PMC 404118.PMID 15087502.
  2. ^Cowart M, Latshaw SP, Bhatia P, Daanen JF, Rohde J, Nelson SL, et al. (July 2004). "Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction".Journal of Medicinal Chemistry.47 (15):3853–3864.doi:10.1021/jm030505a.PMID 15239663.
  3. ^Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, et al. (December 2006). "Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction".Journal of Medicinal Chemistry.49 (25):7450–7465.doi:10.1021/jm060662k.PMID 17149874.
  4. ^Newman-Tancredi A, Heusler P, Martel JC, Ormière AM, Leduc N, Cussac D (May 2008)."Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells".The International Journal of Neuropsychopharmacology.11 (3):293–307.doi:10.1017/S1461145707008061.PMID 17897483.
  5. ^Marona-Lewicka D, Chemel BR, Nichols DE (April 2009)."Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI".Psychopharmacology.203 (2):265–277.doi:10.1007/s00213-008-1238-0.PMID 18604600.
Erectile dysfunction
Prostaglandins (E)
PDE5 inhibitors
Alpha blockers
Dopamine agonists
Melanocortin agonists
Others
Premature ejaculation
SRIs/SSRIs
Oxytocinantagonists
Local anesthetics
D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists
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