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| Other names | 3-CPM; PAL-594; PAL594 |
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| Formula | C11H14ClNO |
| Molar mass | 211.69 g·mol−1 |
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3-Chlorophenmetrazine (3-CPM; code namePAL-594) is arecreationaldesigner drug withstimulant effects.[1][2] It is asubstituted phenylmorpholinederivative, closely related to better known drugs such asphenmetrazine and3-fluorophenmetrazine (3-FPM; PAL-593).[1][2]
The drug has been shown to act as anorepinephrine–dopamine releasing agent (NDRA) with additional weakserotonin release.[1][2] ItsEC50Tooltip half-maximal effective concentration values for induction ofmonoamine release are 27 nM fordopamine, 75 nM fornorepinephrine, and 301 nM for serotonin in rat brainsynaptosomes.[1][2] Hence, it releases dopamine about 3-fold morepotently than norepinephrine and about 11-fold more potently than serotonin.[1][2]
Similarly tocis-4-methylaminorex, the drug is notable in being one of the mostselectivedopamine releasing agents (DRAs) known, although it still has substantial capacity to release norepinephrine.[1][2]
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